Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
VA Connecticut Healthcare System, West Haven, Connecticut, USA.
J Womens Health (Larchmt). 2023 Aug;32(8):852-857. doi: 10.1089/jwh.2023.0015.
There is a critical need for interdisciplinary and translational scientists to apply sex as a biological variable (SABV) research to address knowledge gaps in the health of women. In 2018, the Office of Research on Women's Health (ORWH) partnered with several National Institute of Health (NIH) Institutes and Centers to expand the Specialized Centers of Research (SCOR) Excellence (SCORE) Programs (together referred to as SCOR/E) with an important feature-the Career Enhancement Core (CEC). The SCORE CEC mentors early career investigators to become the next generation of biomedical and behavioral researchers focused on SABV and women's health. In this article, we outline our approach at the Yale University SCORE to support early career trajectories through the provision of salary support, educational curricula, translational mentorship, pilot project funding, and professional development. Using the Yale-SCOR/E CEC Programs as instructional models, we highlight critical measures of academic success, namely grant funding and publications, among early career investigators. At Yale University, 12 pilot projects funded by the SCOR/E Programs resulted in 14 extramural grants, amounting to an $80 return on every $1 invested in "seed" funding. So far, our SCOR/E Programs have resulted in 129 publications, 83% of which were first-authored by trainees, and 100% of trainees continued research careers with an emphasis on SABV. Finally, we provide recommendations on how biomedical scientists can apply SABV in their studies of major medical conditions in an interdisciplinary and integrative way.
目前，跨学科和转化科学家迫切需要将性别视为生物变量（SABV）研究应用于解决女性健康知识空白问题。2018 年，妇女健康办公室（ORWH）与多个国立卫生研究院（NIH）研究所和中心合作，通过一个重要的特色——职业发展核心（CEC）扩展专门研究中心卓越（SCORE）计划（统称为 SCORE/E）。SCORE CEC 指导早期职业研究人员成为下一代专注于 SABV 和女性健康的生物医学和行为研究人员。在本文中，我们概述了耶鲁大学 SCORE 的方法，通过提供工资支持、教育课程、转化指导、试点项目资金和职业发展来支持早期职业轨迹。我们使用耶鲁-SCORE/E CEC 计划作为教学模型，强调了早期职业研究人员的关键学术成功措施，即资助资金和出版物。在耶鲁大学，12 个由 SCORE/E 计划资助的试点项目共获得了 14 项外部资助，“种子”资金的投资回报率为 1 美元回报 80 美分。到目前为止，我们的 SCORE/E 计划已产生 129 篇出版物，其中 83%的出版物由受训人员撰写，100%的受训人员继续从事以 SABV 为重点的研究工作。最后，我们提供了关于生物医学科学家如何以跨学科和综合的方式将 SABV 应用于主要医疗状况研究的建议。
