Department of Radiology, Mayo Clinic, Rochester, Minnesota.
Department of Health Sciences Research, and Mayo Clinic, Rochester, Minnesota.
J Womens Health (Larchmt). 2020 Jun;29(6):865-867. doi: 10.1089/jwh.2019.8066. Epub 2020 Mar 24.
Incorporating sex as a biological variable (SABV) into basic and medical research requires a deliberate plan that weaves concepts of basic genetics, cellular and molecular physiology, and pharmacology into translational medicine. An R4 approach (Right content to the Right learner at the Right time with the Right modality) allows for content to be available in a variety of formats that reinforces the concepts at staged levels of integration. Weaving SABV throughout the varied formats of the R4 approach within the Clinical and Translational Research Training Programs, into the mentoring and training of scholars in NIH Building Interdisciplinary Careers in Women's Health (BIRCWH), and into the Career Enhancement Core of the Specialized Centers of Research Excellence (SCORE) on sex differences through curriculum, case-based approach and journal clubs, and workshops ensures that learners grasp its fundamental relevancy to their own research and beyond. In addition, the collaborative work among the BIRCWH and SCORE programs brings collective expertise from centers around the United States to individual programs through development of best practices and materials. These collective efforts assure that the next generation of basic, clinical, and translational scientists will bring the dimension of SABV into their research and clinical practice.
将性别作为生物学变量（SABV）纳入基础和医学研究需要一个精心策划的计划，将基础遗传学、细胞和分子生理学以及药理学的概念纳入转化医学。R4 方法（在正确的时间以正确的方式向正确的学习者提供正确的内容）允许以各种格式提供内容，从而在整合的各个阶段强化概念。将 SABV 贯穿于 R4 方法的各种格式中，包括临床和转化研究培训计划、NIH 建立女性健康跨学科职业（BIRCWH）学者的指导和培训，以及通过课程、基于案例的方法和期刊俱乐部以及研讨会将性别的卓越研究中心（SCORE）的职业提升核心纳入其中，以确保学习者掌握其对自己研究及其他领域的基本相关性。此外，BIRCWH 和 SCORE 计划之间的合作工作通过制定最佳实践和材料，将来自美国各地中心的集体专业知识带到各个计划中。这些共同努力确保下一代基础、临床和转化科学家将 SABV 维度纳入他们的研究和临床实践。
