G. Oppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
J Womens Health (Larchmt). 2023 Aug;32(8):869-876. doi: 10.1089/jwh.2022.0504.
The Specialized Center of Research Excellence (SCORE) on sex differences at University of California, Los Angeles (UCLA) has a long track record studying bidirectional interactions between different organs and the brain in health and disease with a strong focus on sex as a biological variable (SABV). While the initial focus was on brain-gut interactions in irritable bowel syndrome (IBS), one of the most common disorders of gut-brain interaction, the scope of our Center's research has expanded to a range of different diseases, including inflammatory bowel disease, alcohol use disorder, obesity, urological chronic pelvic pain syndrome, and vulvodynia. This expansion of research focused on the role of brain-body and brain-gut microbiome interactions in these various disorders, aligning well with the increasing importance of multidisciplinary and interdisciplinary team science. The SCORE's Career Enhancement Core (CEC) has modeled team science as applied to SABV research, with educational and training opportunities, a mentoring program, seed grant funding, and other career development experiences that enable mentees to work across the disciplines involved in brain body research. The CEC goals are: (1) To provide seed grant funds for innovative research relevant to the overall SCORE mission and research program; (2) to recruit and foster the career development of students, trainees, and junior investigators who conduct research focused on sex differences or women's health in IBS and chronic constipation and other brain-gut disorders; (3) to facilitate and promote collaboration between the UCLA SCORE and other academic programs involved in women's health education and research; and (4) to promote the importance of SABV through community outreach using collaborative and innovative approaches. These goals focus on establishing the leading research center in sex differences in basic, translational, and clinical aspects of brain-body interactions and on providing women and underrepresented individuals with research opportunities needed to become independent investigators.
加利福尼亚大学洛杉矶分校（UCLA）性差异专业卓越研究中心（SCORE）在健康和疾病中研究不同器官和大脑之间的双向相互作用方面有着悠久的历史，其研究重点是将性别作为生物学变量（SABV）。虽然最初的重点是肠脑相互作用在肠易激综合征（IBS）中的作用，这是最常见的肠脑相互作用疾病之一，但我们中心的研究范围已经扩大到一系列不同的疾病，包括炎症性肠病、酒精使用障碍、肥胖、泌尿科慢性骨盆疼痛综合征和外阴痛。这种对大脑-身体和大脑-肠道微生物组相互作用在这些各种疾病中的作用的研究扩展，与多学科和跨学科团队科学的重要性日益增加相一致。SCORE 的职业发展核心（CEC）将团队科学模式应用于 SABV 研究，提供教育和培训机会、指导计划、种子资助以及其他职业发展经验，使被指导者能够跨参与大脑身体研究的学科工作。CEC 的目标是：（1）为与 SCORE 总体使命和研究计划相关的创新研究提供种子资助；（2）招募和培养从事与 IBS 和慢性便秘等大脑-肠道疾病中的性别差异或女性健康相关研究的学生、学员和初级研究人员的职业发展；（3）促进 UCLA SCORE 与其他参与女性健康教育和研究的学术计划之间的合作；（4）通过使用协作和创新方法进行社区外展，宣传 SABV 的重要性。这些目标侧重于建立在大脑-身体相互作用的基础、转化和临床方面的性别差异领先研究中心，并为女性和代表性不足的个人提供成为独立研究人员所需的研究机会。
