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基于深度学习和埃博拉优化搜索算法的肺癌 CT 扫描自动检测和分类。

Automatic detection and classification of lung cancer CT scans based on deep learning and ebola optimization search algorithm.

机构信息

Department of Computer Science, Faculty of Mathematical and Computer Sciences, University of Gezira, Wad Madani, Sudan.

School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, King Edward Avenue, Pietermaritzburg Campus, Pietermaritzburg, KwaZulu-Natal, South Africa.

出版信息

PLoS One. 2023 Aug 17;18(8):e0285796. doi: 10.1371/journal.pone.0285796. eCollection 2023.

Abstract

Recently, research has shown an increased spread of non-communicable diseases such as cancer. Lung cancer diagnosis and detection has become one of the biggest obstacles in recent years. Early lung cancer diagnosis and detection would reliably promote safety and the survival of many lives globally. The precise classification of lung cancer using medical images will help physicians select suitable therapy to reduce cancer mortality. Much work has been carried out in lung cancer detection using CNN. However, lung cancer prediction still becomes difficult due to the multifaceted designs in the CT scan. Moreover, CNN models have challenges that affect their performance, including choosing the optimal architecture, selecting suitable model parameters, and picking the best values for weights and biases. To address the problem of selecting optimal weight and bias combination required for classification of lung cancer in CT images, this study proposes a hybrid metaheuristic and CNN algorithm. We first designed a CNN architecture and then computed the solution vector of the model. The resulting solution vector was passed to the Ebola optimization search algorithm (EOSA) to select the best combination of weights and bias to train the CNN model to handle the classification problem. After thoroughly training the EOSA-CNN hybrid model, we obtained the optimal configuration, which yielded good performance. Experimentation with the publicly accessible Iraq-Oncology Teaching Hospital / National Center for Cancer Diseases (IQ-OTH/NCCD) lung cancer dataset showed that the EOSA metaheuristic algorithm yielded a classification accuracy of 0.9321. Similarly, the performance comparisons of EOSA-CNN with other methods, namely, GA-CNN, LCBO-CNN, MVO-CNN, SBO-CNN, WOA-CNN, and the classical CNN, were also computed and presented. The result showed that EOSA-CNN achieved a specificity of 0.7941, 0.97951, 0.9328, and sensitivity of 0.9038, 0.13333, and 0.9071 for normal, benign, and malignant cases, respectively. This confirms that the hybrid algorithm provides a good solution for the classification of lung cancer.

摘要

最近,研究表明,癌症等非传染性疾病的传播有所增加。肺癌的诊断和检测已成为近年来最大的障碍之一。早期肺癌的诊断和检测将可靠地促进全球许多生命的安全和生存。使用医学图像对肺癌进行精确分类将有助于医生选择合适的治疗方法,降低癌症死亡率。已经在使用 CNN 进行肺癌检测方面开展了大量工作。然而,由于 CT 扫描的多方面设计,肺癌预测仍然变得困难。此外,CNN 模型存在影响其性能的挑战,包括选择最佳架构、选择合适的模型参数以及为权重和偏差选择最佳值。为了解决 CT 图像中肺癌分类所需的最优权重和偏差组合选择问题,本研究提出了一种混合元启发式和 CNN 算法。我们首先设计了一个 CNN 架构,然后计算模型的解向量。将得到的解向量传递给埃博拉优化搜索算法 (EOSA),以选择最佳的权重和偏差组合来训练 CNN 模型以处理分类问题。在彻底训练 EOSA-CNN 混合模型后,我们获得了最佳配置,从而获得了良好的性能。使用公开的伊拉克肿瘤教学医院/国家癌症疾病中心 (IQ-OTH/NCCD) 肺癌数据集进行实验表明,EOSA 元启发式算法的分类准确率为 0.9321。同样,还计算并呈现了 EOSA-CNN 与其他方法(即 GA-CNN、LCBO-CNN、MVO-CNN、SBO-CNN、WOA-CNN 和经典 CNN)的性能比较。结果表明,EOSA-CNN 对正常、良性和恶性病例的特异性分别为 0.7941、0.97951、0.9328 和敏感性分别为 0.9038、0.13333 和 0.9071。这证实了混合算法为肺癌分类提供了良好的解决方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3891/10434933/3267ab003d08/pone.0285796.g001.jpg

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