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紧急胰十二指肠切除术病例系列:其适应症和结果是什么?

A case series of emergency pancreaticoduodenectomies: What were their indications and outcomes?

作者信息

Lee Kit-Fai, Kung Janet Wui Cheung, Fung Andrew Kai Yip, Lok Hon-Ting, Chong Charing Ching Ning, Wong John, Ng Kelvin Kai Chai, Lai Paul Bo San

机构信息

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

出版信息

Ann Hepatobiliary Pancreat Surg. 2023 Nov 30;27(4):437-442. doi: 10.14701/ahbps.23-035. Epub 2023 Aug 21.

Abstract

Emergency pancreaticoduodenectomy (EPD) is a rarely performed operation. It is important to know the indications and outcomes of EPD to have a better understanding of its application in clinical practice. A review of eight consecutive cases of EPD was done. Between January 2003 and December 2021, 8 out of 370 patients (2.2%) in a single center received pancreaticoduodenectomy as emergency. There were six males and two females with a median age of 45.5 years. The indications were trauma in three patients, bleeding tumors in two patients, and one patient each in obstructing duodenal tumor, postoperative complication and post-endoscopic retrograde cholangiopancreatography (ERCP) complication. The median operative time and blood loss were 427.5 minutes and 1,825 mL, respectively. There was no operative mortality. Seven patients (87.5%) had postoperative complications. Three patients (37.5%) developed postoperative grade B pancreatic fistula. The median postoperative hospital stay was 23.5 days. Five patients were still alive while three patients survived for 13, 31, and 42 months after the operation. The causes of death were recurrent tumors in two patients, and sepsis in one patient. According to this case series, EPD is associated with increased morbidity and pancreatic fistula, but is still deserved in life-threatening situations and long-term survival is possible after EPD.

摘要

急诊胰十二指肠切除术(EPD)是一种很少实施的手术。了解EPD的适应症和结果对于更好地理解其在临床实践中的应用很重要。对连续8例EPD病例进行了回顾。在2003年1月至2021年12月期间,单中心370例患者中有8例(2.2%)接受了急诊胰十二指肠切除术。其中男性6例,女性2例,中位年龄45.5岁。适应症包括3例创伤、2例出血性肿瘤、1例十二指肠梗阻性肿瘤、1例术后并发症和1例内镜逆行胰胆管造影(ERCP)术后并发症。中位手术时间和失血量分别为427.5分钟和1825毫升。无手术死亡病例。7例(87.5%)患者有术后并发症。3例(37.5%)发生术后B级胰瘘。术后中位住院时间为23.5天。5例患者仍存活,3例患者术后分别存活13、31和42个月。死亡原因是2例复发性肿瘤和1例败血症。根据该病例系列,EPD与发病率增加和胰瘘有关,但在危及生命的情况下仍值得实施,EPD术后有可能实现长期生存。

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Pancreaticodudonectomy in trauma: One or two stages?创伤性胰十二指肠切除术:一期还是二期?
Injury. 2020 Mar;51(3):592-596. doi: 10.1016/j.injury.2020.01.018. Epub 2020 Jan 24.
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Emergency pancreatic surgery--demanding and dangerous.急诊胰腺手术——要求高且风险大。
Langenbecks Arch Surg. 2015 Oct;400(7):837-41. doi: 10.1007/s00423-015-1321-z. Epub 2015 Jul 7.

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