从尼日利亚一名被诊断患有复发性菌尿症的人类患者身上分离出的携带CMH-3的ST473的基因组序列草图。
Draft genome sequence of ST473 harbouring CMH-3 isolated from a human patient diagnosed with recurrent bacteriuria in Nigeria.
作者信息
David Ebuka Elijah, Igwenyi Ikechuku Okorie, Iroha Ifeanyichukwu Romanus, Martins Layla Farage, Uceda-Campos Guillermo, da Silva Aline Maria
机构信息
Department of Biochemistry, Alex Ekwueme Federal University, Ndufu-Alike, Ikwo, Nigeria.
Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Sao Paulo, Brazil.
出版信息
Access Microbiol. 2023 Jul 6;5(7). doi: 10.1099/acmi.0.000565.v3. eCollection 2023.
Abstract
is among the most frequently isolated species described in clinical infections and is commonly associated with a multidrug resistance (MDR) phenotype. We present the draft genome sequence of a MDR isolated in Nigeria from the urine sample of an adult male outpatient diagnosed with symptomatic recurrent bacteriuria. The isolate was found to be resistant to ceftriaxone, cefotaxime, cefepime and levofloxacin. Genome analysis revealed the presence of the beta-lactamase chromosomal gene CMH-3, which may be responsible for the antibiotic resistance observed in the recurrent urinary tract infection.
摘要
是临床感染中最常分离出的物种之一，通常与多重耐药（MDR）表型相关。我们展示了从一名被诊断为有症状复发性菌尿的成年男性门诊患者尿液样本中分离出的一株多重耐药菌的基因组序列草图。该分离株对头孢曲松、头孢噻肟、头孢吡肟和左氧氟沙星耐药。基因组分析显示存在β-内酰胺酶染色体基因CMH-3，这可能是复发性尿路感染中观察到的抗生素耐药性的原因。
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