Medical Students Research Committee, Shahed University, Tehran, Iran.
Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
J Neurol. 2023 Dec;270(12):5711-5718. doi: 10.1007/s00415-023-11950-5. Epub 2023 Aug 24.
There are limited data on HHV-7 meningitis and this systematic review used electronic search to gather pieces of evidence regarding its characteristics. Nine articles were included which three were case reports and the rest of the articles were retrospective studies. Altogether, 32 cases were described in the literature that 13 were females and 26 were aged less than 16 years old. The HHV-7 meningitis has been reported in any season, especially in winter. It affected both immunocompetent and immunocompromised individuals and mostly presented with fever and headache, however rash and seizure have also been documented. The CSF analysis in general showed an elevated range of cell count with lymphocytic predominance and normal to slightly elevated protein levels. Thirteen patients did not receive treatment for HHV-7 meningitis and full recovery was gained in the majority of cases after about 10 days. This review summarizes characteristics of HHV-7 meningitis in the literature, and yet epidemiological studies are needed to shed more light which eventually could be helpful for the diagnosis and management of this disease.
关于 HHV-7 脑膜炎的数据有限，本系统评价通过电子检索收集了有关其特征的证据片段。共纳入 9 篇文章，其中 3 篇为病例报告，其余为回顾性研究。文献中总共描述了 32 例病例，其中 13 例为女性，26 例年龄小于 16 岁。HHV-7 脑膜炎在任何季节都有报告，特别是在冬季。它影响免疫功能正常和免疫功能低下的个体，主要表现为发热和头痛，但也有皮疹和癫痫发作的报道。一般来说，CSF 分析显示细胞计数升高，以淋巴细胞为主，蛋白水平正常或略有升高。13 例患者未接受 HHV-7 脑膜炎治疗，大多数患者在大约 10 天后完全康复。本综述总结了文献中 HHV-7 脑膜炎的特征，但仍需要开展流行病学研究，以进一步阐明该病，最终有助于该病的诊断和治疗。
