Rempoła B, Demkowicz-Dobrzański K, Fikus M
Mutat Res. 1986 Oct;172(1):47-50. doi: 10.1016/0165-1218(86)90104-7.
Tilorone and its aza-analogs, as well as CMA and its butyric analog (CNPA) were investigated as potential genotoxic agents by the SOS Chromotest. The SOS-inducing potency values (SOSIP) were 0.0033 and 0.0009 for SAF and vivakorfen, respectively, after activation with S9 fraction of mouse liver only. In contrast, an SOSIP value for tilorone of 0.0011 was observed in a non-activated assay. The SOSIPs of investigated compounds were low and comparable to the lowest values determined for other genotoxins. CMA and CNPA were not SOS inducers in any test system.
通过SOS色变试验研究了替洛隆及其氮杂类似物，以及CMA及其丁酸类似物（CNPA）作为潜在的遗传毒性剂。仅在用小鼠肝脏的S9组分激活后，SAF和维伐考芬的SOS诱导效力值（SOSIP）分别为0.0033和0.0009。相比之下，在未激活的试验中观察到替洛隆的SOSIP值为0.0011。所研究化合物的SOSIP值较低，与其他遗传毒素测定的最低值相当。在任何测试系统中，CMA和CNPA都不是SOS诱导剂。
