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采用新型假型 SARS-CoV-2 病毒在高速空气流速垂直式风洞中评估抗病毒过滤器。

Assessment of novel antiviral filter using pseudo-type SARS-CoV-2 virus in fast air velocity vertical-type wind tunnel.

机构信息

Research Department, DreamTec Cytokines Limited, Hong Kong, China.

School of Science and Technology, Hong Kong Metropolitan University, Hong Kong, China.

出版信息

Sci Rep. 2023 Aug 25;13(1):13947. doi: 10.1038/s41598-023-41245-8.

DOI:10.1038/s41598-023-41245-8
PMID:37626166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10457382/
Abstract

Current evidence suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can remain suspended spread in aerosols for longer period of time under poorly ventilated indoor setting. To minimize spreading, application of antiviral filter to capture infectious aerosols and to inactivate SARS-CoV-2 can be a promising solution. This study aimed to develop a method to assess simultaneously the filtration and removal efficiency of aerosolized pseudo-type SARS-CoV-2 using a vertical-type wind tunnel with relatively high face velocity (1.3 m/s). Comparing with the untreated spunlace non-woven filter, the C-POLAR™ treated filter increased the filtration efficiency from 74.2 ± 11.5% to 97.2 ± 1.7%, with the removal efficiency of 99.4 ± 0.051%. The results provided not only solid evidence to support the effectiveness of the cationic polymeric coated filter in fighting against the SARS-CoV-2 pandemic, but also a method to test viral filtration and removal efficiency under relative fast air velocity and with a safer environment to the operators.

摘要

目前的证据表明,在通风不良的室内环境下,严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)可以在气溶胶中长时间悬浮传播。为了最大程度地减少传播,应用抗病毒过滤器来捕获传染性气溶胶并灭活 SARS-CoV-2 可能是一种有前途的解决方案。本研究旨在开发一种方法,使用具有相对较高迎面风速(1.3 m/s)的垂直式风洞,同时评估雾化伪型 SARS-CoV-2 的过滤和去除效率。与未经处理的纺粘无纺过滤器相比,C-POLAR™处理的过滤器将过滤效率从 74.2±11.5%提高到 97.2±1.7%,去除效率达到 99.4±0.051%。该结果不仅为阳离子聚合物涂层过滤器在抗击 SARS-CoV-2 大流行方面的有效性提供了确凿证据,还为在相对较快的空气速度下测试病毒过滤和去除效率提供了一种方法,同时对操作人员来说更安全。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac7/10457382/956209b035c7/41598_2023_41245_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac7/10457382/b24566a084a0/41598_2023_41245_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac7/10457382/956209b035c7/41598_2023_41245_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac7/10457382/b24566a084a0/41598_2023_41245_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac7/10457382/956209b035c7/41598_2023_41245_Fig2_HTML.jpg

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本文引用的文献

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The dynamics of SARS-CoV-2 infectivity with changes in aerosol microenvironment.SARS-CoV-2 感染性随气溶胶微环境变化的动力学。
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Novel sustainable filter for virus filtration and inactivation.
新型可持续病毒过滤和灭活滤器。
Sci Rep. 2022 Jun 1;12(1):9109. doi: 10.1038/s41598-022-13316-9.
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Instant inactivation of aerosolized SARS-CoV-2 by dielectric filter discharge.介质阻挡放电对气溶胶化 SARS-CoV-2 的即时灭活作用。
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The effect of glycosylation of SARS-CoV-2 spike protein on the virus interaction with the host cell ACE2 receptor.严重急性呼吸综合征冠状病毒2(SARS-CoV-2)刺突蛋白糖基化对病毒与宿主细胞血管紧张素转换酶2(ACE2)受体相互作用的影响
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Are photocatalytic processes effective for removal of airborne viruses from indoor air? A narrative review.光催化过程是否可有效去除室内空气中的空气传播病毒?一项叙述性综述。
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