Department of Nano-Bio Convergence, Korea Institute of Materials Science, Changwon, Republic of Korea.
Clinical Research Centre, Masan National Tuberculosis Hospital, Changwon, Republic of Korea.
PLoS One. 2022 May 19;17(5):e0268049. doi: 10.1371/journal.pone.0268049. eCollection 2022.
This study aimed to evaluate the instant inactivation effect of dielectric filter discharge (DFD) on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) aerosols. The filter consisted of one layer of ZrO2 beads covered by aluminum mesh electrodes; this porous structure of DFD part generates filter-type surface discharge and reactive oxygen species. In a closed cylindrical chamber, DFD treated air flow containing SARS-CoV-2 aerosols, primarily composed of particle diameters of ≤ 1 μm. A polypropylene melt-blown filter collected the treated bioaerosols for inactivation analysis. Plaque and polymerase chain reaction assays showed that the aerosolized SARS-CoV-2 that passed through the filter were more than 99.84% inactivated with degradation of SARS-CoV-2 genes (ORF1ab and E). However, ozone exposure without DFD passage was not found to be effective for bioaerosol inactivation in plaque assay.
本研究旨在评估介质阻挡放电（DFD）对严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）气溶胶的即时灭活效果。该过滤器由一层 ZrO2 珠粒组成，表面覆盖有铝网电极；DFD 部分的这种多孔结构会产生过滤型表面放电和活性氧物质。在一个封闭的圆柱形腔室中，DFD 处理的空气流中含有 SARS-CoV-2 气溶胶，主要由直径≤1μm 的颗粒组成。聚丙烯熔喷过滤器收集经过处理的生物气溶胶进行灭活分析。噬斑和聚合酶链反应检测表明，通过过滤器的气溶胶化 SARS-CoV-2 有超过 99.84%被灭活，SARS-CoV-2 基因（ORF1ab 和 E）降解。然而，在噬斑检测中，未发现没有 DFD 通过的臭氧暴露对生物气溶胶的灭活有效。
