Akram Zubair, Raza Ali, Mehdi Muhammad, Arshad Anam, Deng Xiling, Sun Shiguo
Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China.
College of Chemistry & Pharmacy, Northwest A&F University, Xianyang 712100, China.
Nanomaterials (Basel). 2023 Aug 14;13(16):2336. doi: 10.3390/nano13162336.
In nanotechnology, the synthesis of carbon quantum dots (CQDs) by mixed doping with metals and non-metals has emerged as an appealing path of investigation. This review offers comprehensive insights into the synthesis, properties, and emerging applications of mixed-doped CQDs, underlining their potential for revolutionary advancements in chemical sensing, biosensing, bioimaging, and, thereby, contributing to advancements in diagnostics, therapeutics, and the under standing of complex biological processes. This synergistic combination enhances their sensitivity and selectivity towards specific chemical analytes. The resulting CQDs exhibit remarkable fluorescence properties that can be involved in precise chemical sensing applications. These metal-modified CQDs show their ability in the selective and sensitive detection from Hg to Fe and Mn ions. By influencing their exceptional fluorescence properties, they enable precise detection and monitoring of biomolecules, such as uric acid, cholesterol, and many antibiotics. Moreover, when it comes to bioimaging, these doped CQDs show unique behavior towards detecting cell lines. Their ability to emit light across a wide spectrum enables high-resolution imaging with minimal background noise. We uncover their potential in visualizing different cancer cell lines, offering valuable insights into cancer research and diagnostics. In conclusion, the synthesis of mixed-doped CQDs opens the way for revolutionary advancements in chemical sensing, biosensing, and bioimaging. As we investigate deeper into this field, we unlock new possibilities for diagnostics, therapeutics, and understanding complex biological processes.
在纳米技术领域，通过金属与非金属混合掺杂来合成碳量子点（CQDs）已成为一条引人注目的研究途径。本综述全面深入地探讨了混合掺杂碳量子点的合成、性质及新兴应用，强调了它们在化学传感、生物传感、生物成像方面取得革命性进展的潜力，从而推动诊断学、治疗学的发展以及对复杂生物过程的理解。这种协同组合提高了它们对特定化学分析物的灵敏度和选择性。所得的碳量子点展现出卓越的荧光特性，可用于精确的化学传感应用。这些金属修饰的碳量子点在从汞到铁和锰离子的选择性和灵敏检测中显示出其能力。通过影响其独特的荧光特性，它们能够精确检测和监测生物分子，如尿酸、胆固醇和多种抗生素。此外，在生物成像方面，这些掺杂的碳量子点在检测细胞系时表现出独特的行为。它们在宽光谱范围内发光的能力使得能够以最小的背景噪声进行高分辨率成像。我们揭示了它们在可视化不同癌细胞系方面的潜力，为癌症研究和诊断提供了有价值的见解。总之，混合掺杂碳量子点的合成开启了化学传感、生物传感和生物成像领域革命性进展的道路。随着我们对该领域的深入研究，我们为诊断学、治疗学以及理解复杂生物过程解锁了新的可能性。
