Jha Gaurav, Sharma Ritika B, Sridhar Sruthi, Hayagreev Disha, Sinha Tanya, Kaur Harsimran, Das Adrija, Bollineni Reddy Lahari
Trauma and Orthopaedics, Leicester Royal Infirmary, Leicester, GBR.
Geriatrics, Pinderfields General Hospital, MidYorkshire, GBR.
Cureus. 2024 Oct 31;16(10):e72808. doi: 10.7759/cureus.72808. eCollection 2024 Oct.
Cardiovascular diseases (CVDs) present a significant global health burden and remain the leading cause of morbidity and mortality worldwide. Conventional pharmacological therapies have yielded limited success in addressing the underlying pathophysiology of these diseases, leading to the exploration of novel therapeutic approaches. Nanotechnology is transforming cardiovascular disease management by enabling the engineering of materials at the atomic and molecular levels. This has led to the development of advanced diagnostic tools with unparalleled accuracy and sensitivity in detecting these diseases. By enabling targeted drug delivery, enhancing imaging techniques, and facilitating personalized therapies, nanotechnology promises significant advancements in the diagnosis, treatment, and prevention of cardiovascular diseases. This narrative review provides a comprehensive outlook on the recent advancements in nanoparticle-based therapies for cardiovascular diseases. We delve into the diverse applications of various nanoparticle types, exploring their potential to surpass the limitations of conventional treatments and improve clinical outcomes. Additionally, we critically examine the challenges and future directions of this rapidly evolving field, emphasizing the need for rigorous clinical evaluation.
心血管疾病（CVDs）是全球重大的健康负担，仍是全球发病和死亡的主要原因。传统药物疗法在解决这些疾病的潜在病理生理学问题上取得的成功有限，这促使人们探索新的治疗方法。纳米技术正在改变心血管疾病的管理方式，它能够在原子和分子水平上对材料进行工程设计。这带来了先进的诊断工具，在检测这些疾病方面具有无与伦比的准确性和灵敏度。通过实现靶向药物递送、增强成像技术以及促进个性化治疗，纳米技术有望在心血管疾病的诊断、治疗和预防方面取得重大进展。这篇叙述性综述全面展望了基于纳米颗粒的心血管疾病治疗的最新进展。我们深入探讨了各种类型纳米颗粒的不同应用，探索它们超越传统治疗局限性并改善临床结果的潜力。此外，我们批判性地审视了这个快速发展领域的挑战和未来方向，强调了进行严格临床评估的必要性。
