Rahman Khan Mohammad Mizanur, Asrafali Shakila Parveen, Periyasamy Thirukumaran
Department of Mechanical Engineering, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si 13120, Gyeonggi-do, Republic of Korea.
Department of Fiber System Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Gyeongbuk, Republic of Korea.
Polymers (Basel). 2024 Sep 24;16(19):2701. doi: 10.3390/polym16192701.
The achievement of large-scale applications of plasma-based polymers in biomedical sectors does not satisfy the appropriate level although a substantial amount of research is already performed. In this context, further investigations are necessary to design and synthesize plasma polymers for biomedical applications. Among the polymeric materials, plasma-based polymers have attracted substantial attention owing to their numerous advantages like faster processing, lower costs, eco-friendly waste, biocompatibility, and versatility, making them excellent materials for biomedical applications. Further, polymer synthesis using plasma polymerization techniques can avoid the time-consuming conventional multistep synthesis procedure. Plasma polymerization also offers a significant solution to overcome the numerous difficulties in the traditional approach where polymers can be directly attached to the desired surface using a plasma process, without disturbing the growing chain, and, thus, prevent an additional process such as grafting. Nevertheless, the design of appropriate plasma-based synthesis methods, optimization of the plasma process parameters, and exploration of polymer-based biocompatibility approaches are still challenging research areas. Regarding the surface morphological features of these plasma polymers, they possess several characteristics, such as wettability, adhesion capacity, and so on, that are important considerations in biomedical applications. In this review, numerous recent approaches to plasma polymerization methods along with different precursor phases used for such kind of synthesis of polymeric materials are discussed. The morphological aspect of the synthesized plasma polymers connected with biomedical applications is also reported in this review. Finally, promising aspects of plasma polymers for biomedical applications are briefly reported in this work. This review may offer an extensive reference for upcoming perceptions of plasma-based polymers and their applications in biomedical sectors.
尽管已经开展了大量研究，但基于等离子体的聚合物在生物医学领域的大规模应用成果仍未达到理想水平。在此背景下，有必要进行进一步研究，以设计和合成用于生物医学应用的等离子体聚合物。在聚合材料中，基于等离子体的聚合物因其具有诸多优势，如加工速度快、成本低、环保废料、生物相容性和多功能性等，而备受关注，使其成为生物医学应用的理想材料。此外，使用等离子体聚合技术进行聚合物合成可以避免传统多步合成过程的耗时问题。等离子体聚合还提供了一个重要的解决方案，以克服传统方法中的诸多困难，即可以通过等离子体过程将聚合物直接附着到所需表面，而不会干扰生长链，从而避免了诸如接枝等额外过程。然而，设计合适的基于等离子体的合成方法、优化等离子体工艺参数以及探索基于聚合物的生物相容性方法仍然是具有挑战性的研究领域。关于这些等离子体聚合物的表面形态特征，它们具有若干特性，如润湿性、粘附能力等，这些都是生物医学应用中的重要考虑因素。在本综述中，讨论了用于此类聚合物材料合成的等离子体聚合方法的众多最新方法以及不同的前驱体相。本综述还报道了与生物医学应用相关的合成等离子体聚合物的形态方面。最后，简要报道了基于等离子体的聚合物在生物医学应用中的前景。本综述可为未来对基于等离子体的聚合物及其在生物医学领域应用的认识提供广泛参考。
