Liu Xiaoyan, Chu Zhaoyou, Chen Benjin, Ma Yan, Xu Lingling, Qian Haisheng, Yu Yue
Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, PR China.
Department of Gastroenterology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, PR China.
Mater Today Bio. 2023 Aug 14;22:100765. doi: 10.1016/j.mtbio.2023.100765. eCollection 2023 Oct.
Oxidative stress induced by reactive oxygen species (ROS) is promising treatment approach for pancreatic ductal adenocarcinoma (PDAC), which is typically insensitive to conventional chemotherapy. In this study, BxPC-3 pancreatic cancer cell membrane-coated upconversion nanoparticles/ZnMnS core-shell nanoparticles (abbreviated as BUC@ZMS) were developed for tumor-targeted cancer therapy synergistically oxidative stress and overcoming glutathione (GSH) overexpression. Using a combination of photodynamic therapy (PDT) and chemodynamic therapy (CDT), the BUC@ZMS core-shell nanoparticles were able to elicit the death of pancreatic cancer cells through the high production of ROS. Additionally, the BUC@ZMS core-shell nanoparticles could deplete intracellular GSH and increase the sensitivity of tumor cells to oxidative stress. The results indicated that BUC@ZMS nanoparticles can accumulate specifically in tumor locations and suppress PDAC without generating obvious toxicity. Thus, it was determined that the as-prepared core-shell nanoparticles would be a viable treatment option for solid malignancies.
由活性氧（ROS）诱导的氧化应激是治疗胰腺导管腺癌（PDAC）的一种很有前景的方法，这种癌症通常对传统化疗不敏感。在本研究中，开发了BxPC-3胰腺癌细胞膜包覆的上转换纳米颗粒/ZnMnS核壳纳米颗粒（简称为BUC@ZMS），用于肿瘤靶向癌症治疗，协同产生氧化应激并克服谷胱甘肽（GSH）过表达。通过结合光动力疗法（PDT）和化学动力疗法（CDT），BUC@ZMS核壳纳米颗粒能够通过大量产生活性氧引发胰腺癌细胞死亡。此外，BUC@ZMS核壳纳米颗粒可以消耗细胞内的谷胱甘肽并增加肿瘤细胞对氧化应激的敏感性。结果表明，BUC@ZMS纳米颗粒可以特异性地在肿瘤部位积累并抑制胰腺导管腺癌，而不会产生明显的毒性。因此，确定所制备的核壳纳米颗粒将是实体恶性肿瘤的一种可行治疗选择
