Corbetti F, Malatesta V, Camposampiero A, Mazzi A, Punzi L, Angelini F, Vigo M, Todesco S
Radiology. 1986 Oct;161(1):195-8. doi: 10.1148/radiology.161.1.3763866.
Changes in synovial fluid leukocytes, total protein, and total complement were studied in 58 patients after they underwent single contrast material-enhanced knee arthrography with ionic (sodium iothalamate, sodium meglumine diatrizoate, meglumine iothalamate) and nonionic (iopamidol, iohexol) contrast media. In 30 of 58 cases, 0.3 mg epinephrine was also injected. In patients examined without epinephrine, a significant increase in the number of leukocytes was observed when sodium iothalamate and sodium meglumine diatrizoate were used. When administered with epinephrine all ionic compounds produced significant leukocytosis; articular reactions were most evident in patients examined with sodium salts. No inflammatory changes in the synovial fluid were observed when nonionic compounds were used. These data suggest that sodium-containing compounds produce a greater reaction in the joint compared with other contrast media, nonionic compounds are better tolerated by the joint, and epinephrine increases the articular reaction to ionic contrast media.
对58例患者在使用离子型（碘他拉酸钠、葡甲胺泛影酸钠、碘他拉酸葡甲胺）和非离子型（碘帕醇、碘海醇）造影剂进行单对比剂增强膝关节造影术后，研究了滑液白细胞、总蛋白和总补体的变化。在58例中的30例中，还注射了0.3mg肾上腺素。在未使用肾上腺素检查的患者中，当使用碘他拉酸钠和葡甲胺泛影酸钠时，观察到白细胞数量显著增加。当与肾上腺素一起使用时，所有离子化合物都会产生显著的白细胞增多；在用钠盐检查的患者中关节反应最为明显。当使用非离子化合物时，未观察到滑液有炎症变化。这些数据表明，与其他造影剂相比，含钠化合物在关节中产生的反应更大，非离子化合物在关节中耐受性更好，肾上腺素会增加关节对离子型造影剂的反应。
