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美国 25 个司法管辖区横断面样本中 333 例结核病和 COVID-19 患者的特征和死亡情况。

Characteristics of and Deaths among 333 Persons with Tuberculosis and COVID-19 in Cross-Sectional Sample from 25 Jurisdictions, United States.

出版信息

Emerg Infect Dis. 2023 Oct;29(10):2016-2023. doi: 10.3201/eid2910.230286. Epub 2023 Aug 30.

DOI:10.3201/eid2910.230286
PMID:37647628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10521611/
Abstract

Little is known about co-occurring tuberculosis (TB) and COVID-19 in low TB incidence settings. We obtained a cross-section of 333 persons in the United States co-diagnosed with TB and COVID-19 within 180 days and compared them to 4,433 persons with TB only in 2020 and 18,898 persons with TB during 2017‒2019. Across both comparison groups, a higher proportion of persons with TB-COVID-19 were Hispanic, were long-term care facility residents, and had diabetes. When adjusted for age, underlying conditions, and TB severity, COVID-19 co-infection was not statistically associated with death compared with TB infection only in 2020 (adjusted prevalence ratio 1.0 [95% CI 0.8‒1.4]). Among TB-COVID-19 patients, death was associated with a shorter interval between TB and COVID-19 diagnoses, older age, and being immunocompromised (non-HIV). TB-COVID-19 deaths in the United States appear to be concentrated in subgroups sharing characteristics known to increase risk for death from either disease alone.

摘要

关于低结核病发病率环境中同时发生结核病（TB）和 COVID-19 的情况知之甚少。我们获得了美国在 180 天内同时被诊断患有结核病和 COVID-19 的 333 人的横断面数据，并将其与 2020 年仅有结核病的 4433 人和 2017-2019 年期间患有结核病的 18898 人进行了比较。在这两个比较组中，患有 TB-COVID-19 的人中有更高比例的西班牙裔、长期护理机构居民和患有糖尿病。与仅患有结核病的患者相比，在调整年龄、基础疾病和结核病严重程度后，COVID-19 合并感染与 2020 年的死亡没有统计学关联（调整后的患病率比 1.0 [95%CI 0.8-1.4]）。在 TB-COVID-19 患者中，死亡与结核病和 COVID-19 诊断之间的时间间隔较短、年龄较大以及免疫功能低下（非 HIV）有关。美国的 TB-COVID-19 死亡似乎集中在具有已知会增加单独死于任何一种疾病风险的特征的亚组中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a147/10521611/b3074df71162/23-0286-F4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a147/10521611/b3074df71162/23-0286-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a147/10521611/bc7ac1e259f7/23-0286-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a147/10521611/51790a3079b0/23-0286-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a147/10521611/2bc9269ef8cd/23-0286-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a147/10521611/b3074df71162/23-0286-F4.jpg

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