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弱射频和静磁场对 HT-1080 纤维肉瘤细胞中关键信号分子、细胞内 pH 值、膜电位和细胞生长的影响。

Impact of weak radiofrequency and static magnetic fields on key signaling molecules, intracellular pH, membrane potential, and cell growth in HT-1080 fibrosarcoma cells.

机构信息

Department of Electrical, Computer and Energy Engineering, University of Colorado at Boulder, 425 UCB #1B55, Boulder, CO, 80309, USA.

出版信息

Sci Rep. 2023 Aug 30;13(1):14223. doi: 10.1038/s41598-023-41167-5.

DOI:10.1038/s41598-023-41167-5
PMID:37648766
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10469173/
Abstract

There are substantial concerns that extended exposures to weak radiofrequency (RF) fields can lead to adverse health effects. In this study, HT-1080 fibrosarcoma cells were simultaneously exposed to a static magnetic flux density between 10 [Formula: see text] and 300 [Formula: see text] and RF magnetic fields with amplitudes ranging from 1 nT to 1.5 μT in the frequency range from 1.8 to 7.2 MHz for four days. Cell growth rates, intracellular pH, hydrogen peroxide, peroxynitrite, membrane potential and mitochondrial calcium were measured. Results were dependent on carrier frequency and the magnitude of the RF magnetic field, modulation frequencies and the background static magnetic field (SMF). Iron sulphur (Fe-S) clusters are essential for the generation of reactive oxygen species and reactive nitrogen species (ROS and RNS). We believe the observed changes are associated with hyperfine couplings between the chemically active electrons and nuclear spins. Controlling external magnetic fields may have important clinical implications on aging, cancer, arthritis, and Alzheimer's.

摘要

人们非常担心长时间接触弱射频（RF）场可能会对健康造成不良影响。在这项研究中，HT-1080 纤维肉瘤细胞同时暴露于磁场中，磁场强度在 10 [Formula: see text] 和 300 [Formula: see text] 之间，磁场频率范围为 1.8 到 7.2 MHz，RF 磁场的幅度范围为 1 nT 到 1.5 μT，持续四天。测量细胞生长率、细胞内 pH 值、过氧化氢、过氧亚硝酸盐、膜电位和线粒体钙。结果取决于载波频率和 RF 磁场的幅度、调制频率和背景静磁场（SMF）。铁硫（Fe-S）簇对于活性氧和活性氮物质（ROS 和 RNS）的产生是必不可少的。我们认为观察到的变化与化学活性电子和核自旋之间的超精细耦合有关。控制外部磁场可能对衰老、癌症、关节炎和阿尔茨海默氏症具有重要的临床意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/33acbe2ca839/41598_2023_41167_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/de48f42f1895/41598_2023_41167_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/fbdcfa917ce4/41598_2023_41167_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/8c7d976c3d40/41598_2023_41167_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/3f5cc9aecf70/41598_2023_41167_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/cfa3a1705e4c/41598_2023_41167_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/9729c5244f73/41598_2023_41167_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/3336a253b3a5/41598_2023_41167_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/c9f09c26e918/41598_2023_41167_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/d7cc677a10b2/41598_2023_41167_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/ca60f8c33c52/41598_2023_41167_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/c6b77efa6482/41598_2023_41167_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/33acbe2ca839/41598_2023_41167_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/de48f42f1895/41598_2023_41167_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/fbdcfa917ce4/41598_2023_41167_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/8c7d976c3d40/41598_2023_41167_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/3f5cc9aecf70/41598_2023_41167_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/cfa3a1705e4c/41598_2023_41167_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/9729c5244f73/41598_2023_41167_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/3336a253b3a5/41598_2023_41167_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/c9f09c26e918/41598_2023_41167_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/d7cc677a10b2/41598_2023_41167_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/ca60f8c33c52/41598_2023_41167_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/c6b77efa6482/41598_2023_41167_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1abc/10469173/33acbe2ca839/41598_2023_41167_Fig12_HTML.jpg

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本文引用的文献

[1]
Weak Radiofrequency Field Effects on Chemical Parameters That Characterize Oxidative Stress in Human Fibrosarcoma and Fibroblast Cells.

Biomolecules. 2023-7-13

[2]
An Open Question: Is Non-Ionizing Radiation a Tool for Controlling Apoptosis-Induced Proliferation?

Int J Mol Sci. 2021-10-16

[3]
Effects Induced by a Weak Static Magnetic Field of Different Intensities on HT-1080 Fibrosarcoma Cells.

Bioelectromagnetics. 2021-4

[4]
Towards predicting intracellular radiofrequency radiation effects.

PLoS One. 2019-3-14

[5]
Weak magnetic fields alter stem cell-mediated growth.

Sci Adv. 2019-1-30

[6]
Mitochondrial Rieske iron-sulfur protein in pulmonary artery smooth muscle: A key primary signaling molecule in pulmonary hypertension.

Arch Biochem Biophys. 2019-1-30

[7]
The machineries, regulation and cellular functions of mitochondrial calcium.

Nat Rev Mol Cell Biol. 2018-11

[8]
The Radical-Pair Mechanism of Magnetoreception.

Annu Rev Biophys. 2016-5-16

[9]
Design and fine-tuning redox potentials of metalloproteins involved in electron transfer in bioenergetics.

Biochim Biophys Acta. 2016-5

[10]
Biological Activities of Reactive Oxygen and Nitrogen Species: Oxidative Stress versus Signal Transduction.

Biomolecules. 2015-4-15

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