Faculty of Medicine, University of Aleppo, Aleppo, Syria.
Faculty of Medicine, Damascus University, Damascus, Syria.
J Med Case Rep. 2023 Aug 31;17(1):372. doi: 10.1186/s13256-023-04121-7.
Mediastinal Liposarcoma (ML) is an exceedingly rare neoplasm, accounting for less than 1% of all liposarcomas. Surgical resection is the most effective therapeutic modality, while adjuvant radiation therapy may be recommended for unresectable tumors.
This case report presents a rare case of a 52-year-old Syrian male patient with well-differentiated mediastinal liposarcoma (ML) who presented with exertional dyspnea, cough, and weight loss. Imaging studies revealed a large tumor causing extrinsic compression on the right lung, as well as compression of the heart and great vessels. CT-guided biopsy confirmed a diagnosis of well-differentiated liposarcoma, and the patient underwent surgical resection. The patient had a rapid postoperative recovery and was discharged on the fourth day post-operation, displaying an excellent postoperative status. The patient was followed up for 3 months postoperatively with no recurrence.
This report highlights the significance of incorporating ML into the differential diagnosis of mediastinal masses, particularly in individuals presenting with exertional dyspnea and weight loss. Furthermore, this report provides a comprehensive review of previously reported cases of ML in the medical literature.
纵隔脂肪肉瘤（ML）是一种非常罕见的肿瘤，占所有脂肪肉瘤的比例不到 1%。手术切除是最有效的治疗方式，而对于无法切除的肿瘤，可能会推荐辅助放疗。
本病例报告介绍了一例罕见的 52 岁叙利亚男性患者，患有分化良好的纵隔脂肪肉瘤（ML），表现为活动后呼吸困难、咳嗽和体重减轻。影像学研究显示一个大肿瘤导致右肺受压，以及心脏和大血管受压。CT 引导下的活检证实了分化良好的脂肪肉瘤的诊断，患者接受了手术切除。患者术后恢复迅速，第四天就出院了，术后状态极佳。患者术后随访 3 个月，无复发。
本报告强调了将 ML 纳入纵隔肿块鉴别诊断的重要性，特别是在出现活动后呼吸困难和体重减轻的患者中。此外，本报告还对医学文献中以前报道的 ML 病例进行了全面回顾。
