The Florey, The University of Melbourne, Parkville, Victoria, Australia.
School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.
Proteomics. 2024 Jun;24(11):e2300063. doi: 10.1002/pmic.202300063. Epub 2023 Aug 31.
Lipids play a significant role in maintaining central nervous system (CNS) structure and function, and the dysregulation of lipid metabolism is known to occur in many neurological disorders, including Alzheimer's disease. Here we review what is currently known about lipid dyshomeostasis in Alzheimer's disease. We propose that small extracellular vesicle (sEV) lipids may provide insight into the pathophysiology and progression of Alzheimer's disease. This stems from the recognition that sEV likely contributes to disease pathogenesis, but also an understanding that sEV can serve as a source of potential biomarkers. While the protein and RNA content of sEV in the CNS diseases have been studied extensively, our understanding of the lipidome of sEV in the CNS is still in its infancy.
脂质在维持中枢神经系统 (CNS) 结构和功能方面发挥着重要作用，已知脂质代谢失调发生在许多神经疾病中，包括阿尔茨海默病。在这里，我们综述了目前已知的阿尔茨海默病中的脂质代谢失衡。我们提出，小细胞外囊泡 (sEV) 中的脂质可能为阿尔茨海默病的病理生理学和进展提供新的见解。这源于以下认识，即 sEV 可能有助于疾病的发病机制，但也理解 sEV 可以作为潜在生物标志物的来源。虽然中枢神经系统疾病中小细胞外囊泡的蛋白质和 RNA 含量已经得到了广泛的研究，但我们对中枢神经系统中小细胞外囊泡的脂质组学的理解仍处于起步阶段。
