Juncker Hannah G, van Doesburg Maritt, de Groot Christianne J M, Pajkrt Dasja, Korosi Aniko, van Gils Marit J, van Goudoever Johannes B, van Keulen Britt J
Amsterdam UMC, Vrije Universiteit, University of Amsterdam, Emma Children's Hospital, Amsterdam Reproduction & Development Research Institute, Department of Pediatrics, Amsterdam, the Netherlands.
Swammerdam Institute for Life Sciences - Center for Neuroscience, University of Amsterdam, Amsterdam, the Netherlands.
Heliyon. 2023 Aug 18;9(8):e19218. doi: 10.1016/j.heliyon.2023.e19218. eCollection 2023 Aug.
Moderate exercise results in a significant increase in serum and salivary immunoglobulins. Maternal physical activity might therefore also be a factor influencing antibody levels in human milk. This study aims to determine the influence of physical activity on SARS-CoV-2-specific Immunoglobulin A (IgA) in human milk and Immunoglobulin G (IgG) in serum.
In this prospective cross-sectional cohort study, all lactating women in the Netherlands were eligible to participate. SARS-CoV-2-specific IgA in human milk and IgG in serum were determined using an enzyme-linked immunosorbent assay (ELISA). Data on performed physical activity was collected using the Short Questionnaire to Assess Health enhancing physical activity (SQUASH), which includes intensity and duration of the performed activity.
In total, 356 out of 2312 lactating women tested positive for SARS-CoV-2-specific antibodies in serum. Of them, 323 filled in the questionnaire and were included in the analysis. An association between the activity score and SARS-CoV-2-specific antibodies in human milk ( = 1·035, 95·0% CI = 1·019 to 1·052 = 0·042) and serum ( = 1·019, 95·0% CI = 1·009 to 1·029, = 0·048) was demonstrated. No association was found between the duration of physical activity and SARS-CoV-2-specific antibodies in human milk or serum.
Our findings suggest that physical activity is beneficial for the levels of SARS-CoV-2-specific antibodies in human milk and serum, with the intensity of the physical activity being the most important contributor to this relationship. A higher level of antibodies in human milk might provide better immunological protection for infants against COVID-19.
适度运动可导致血清和唾液免疫球蛋白显著增加。因此，母体的身体活动可能也是影响母乳中抗体水平的一个因素。本研究旨在确定身体活动对母乳中新冠病毒特异性免疫球蛋白A（IgA）和血清中免疫球蛋白G（IgG）的影响。
在这项前瞻性横断面队列研究中，荷兰所有哺乳期妇女均有资格参与。采用酶联免疫吸附测定（ELISA）法测定母乳中新冠病毒特异性IgA和血清中IgG。使用《健康增强身体活动简短问卷》（SQUASH）收集所进行身体活动的数据，该问卷包括所进行活动的强度和持续时间。
在2312名哺乳期妇女中，共有356人血清中新冠病毒特异性抗体检测呈阳性。其中，323人填写了问卷并纳入分析。结果显示活动得分与母乳中（β = 1·035，95·0%CI = 1·019至1·052，P = = 0·042）和血清中（β = 1·019，95·0%CI = 1·009至1·029，P = 0·048）的新冠病毒特异性抗体之间存在关联。未发现身体活动持续时间与母乳或血清中新冠病毒特异性抗体之间存在关联。
我们的研究结果表明，身体活动对母乳和血清中新冠病毒特异性抗体水平有益，身体活动强度是这种关系的最重要促成因素。母乳中较高水平的抗体可能为婴儿提供更好的针对新冠病毒的免疫保护。
