Department of Bioscience Engineering, Research Group Environmental Ecology and Applied Microbiology, University of Antwerp , Antwerp, Belgium.
Department of Obstetrics and Gynaecology, University Hospital Antwerp , Edegem, Belgium.
mBio. 2023 Oct 31;14(5):e0030023. doi: 10.1128/mbio.00300-23. Epub 2023 Sep 1.
The salivary microbiome has been proven to play a crucial role in local and systemic diseases. Moreover, the effects of biological and lifestyle factors such as oral hygiene and smoking on this microbial community have already been explored. However, what was not yet well understood was the natural variation of the saliva microbiome in healthy women and how this is associated with specific use of hormonal contraception and with the number of different sexual partners with whom microbiome exchange is expected regularly. In this paper, we characterized the salivary microbiome of 255 healthy women of reproductive age using an in-depth questionnaire and self-sampling kits. Using the large metadata set, we were able to investigate the associations of several host-related and lifestyle variables with the salivary microbiome profiles. Our study shows a high preservation between individuals.
唾液微生物组已被证明在局部和全身疾病中起着至关重要的作用。此外，已经探讨了生物和生活方式因素（如口腔卫生和吸烟）对该微生物群落的影响。然而，人们还不太了解健康女性唾液微生物组的自然变异，以及这种变异如何与特定的激素避孕使用以及与预计定期进行微生物组交换的不同性伴侣数量相关。在本文中，我们使用深度问卷和自我采样试剂盒对 255 名育龄健康女性的唾液微生物组进行了表征。利用大型元数据集，我们能够调查几个宿主相关和生活方式变量与唾液微生物组特征之间的关联。我们的研究表明个体之间具有高度的保存性。
