Shandong Co-Innovation Center of Classic TCM Formula, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Shandong Co-Innovation Center of Classic TCM Formula, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Phytomedicine. 2023 Nov;120:155027. doi: 10.1016/j.phymed.2023.155027. Epub 2023 Aug 18.
Verbascoside is a natural and water-soluble phenylethanoid glycoside found in several medicinal plants. It has extensive pharmacological effects, including antioxidative and antineoplastic actions, and a wide range of therapeutic effects against depression.
In this review, we appraised preclinical and limited clinical evidence to fully discuss the anti-depression capacity of verbascoside and its holistic characteristics that can contribute to better management of depression in vivo and in vitro models, as well as, its toxicities and medicinal value.
This review was prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A systematic review of 32 preclinical trials published up to April 2023, combined with a comprehensive bioinformatics analysis of network pharmacology and molecular docking, was conducted to elucidate the antidepressant mechanism of action of verbascoside. Studies included in the systematic review were obtained from 7 electronic databases: PubMed, Scopus, Web of Science, Cochrane, ResearchGate, ScienceDirect, and Google Scholar.
Studies on the antidepressant effects of verbascoside showed that various pharmacological mechanisms and pathways, such as modulating the levels of monoamine neurotransmitters, inhibiting hypothalamic-pituitary-adrenal (HPA) axis hyperfunction and promoting neuroprotection may be involved in the process of its action against depression. Verbascoside promotes dopamine (DA) biosynthesis by promoting the expression of tyrosine hydroxylase mRNA and protein, upregulates the expression of 5-hydroxytryptamine receptor 1B (5-HT1B), prominence protein, microtubule-associated protein 2 (MAP2), hemeoxygenase-1 (HO-1), SQSTM1, Recombinant Autophagy Related Protein 5 (ATG5) and Beclin-1, and decreases the expression of caspase-3 and a-synuclein, thus exerting antidepressant effects. We identified seven targets (CCL2, FOS, GABARAPL1, CA9, TYR, CA12, and SQSTM1) and three signaling pathways (glutathione metabolism, metabolism of xenobiotics by cytochrome P450, fluid shear stress and atherosclerosis) as potential molecular biological sites for verbascoside.
These findings provide strong evidence that verbascoside exerts its antidepressant effects through various pharmacological mechanisms. However, further multicentre clinical case-control and molecularly targeted fishing studies are required to confirm the clinical efficacy of verbascoside and its underlying direct targets.
毛蕊花糖苷是一种天然的水溶性苯乙醇苷，存在于多种药用植物中。它具有广泛的药理作用，包括抗氧化和抗肿瘤作用，以及对抑郁症的广泛治疗作用。
在本综述中，我们评估了临床前和有限的临床证据，以充分讨论毛蕊花糖苷的抗抑郁能力及其整体特征，这些特征有助于更好地管理体内和体外抑郁症模型的抑郁，以及其毒性和药用价值。
本综述根据系统评价和荟萃分析的首选报告项目（PRISMA）进行准备。对截至 2023 年 4 月发表的 32 项临床前试验进行了系统评价，并结合网络药理学和分子对接的综合生物信息学分析，阐明了毛蕊花糖苷的抗抑郁作用机制。系统评价中包括的研究来自 7 个电子数据库：PubMed、Scopus、Web of Science、Cochrane、ResearchGate、ScienceDirect 和 Google Scholar。
毛蕊花糖苷抗抑郁作用的研究表明，多种药理机制和途径可能参与其抗抑郁作用过程，如调节单胺神经递质水平、抑制下丘脑-垂体-肾上腺（HPA）轴功能亢进和促进神经保护。毛蕊花糖苷通过促进酪氨酸羟化酶 mRNA 和蛋白的表达来促进多巴胺（DA）的生物合成，上调 5-羟色胺受体 1B（5-HT1B）、突出蛋白、微管相关蛋白 2（MAP2）、血红素加氧酶-1（HO-1）、SQSTM1、自噬相关蛋白 5（ATG5）和 Beclin-1 的表达，降低半胱天冬酶-3 和 a-突触核蛋白的表达，从而发挥抗抑郁作用。我们确定了七个靶点（CCL2、FOS、GABARAPL1、CA9、TYR、CA12 和 SQSTM1）和三个信号通路（谷胱甘肽代谢、细胞色素 P450 代谢的外源性物质、流体剪切应激和动脉粥样硬化）作为毛蕊花糖苷潜在的分子生物学靶点。
这些发现为毛蕊花糖苷通过多种药理机制发挥抗抑郁作用提供了有力证据。然而，需要进一步进行多中心临床病例对照和分子靶向捕捞研究，以确认毛蕊花糖苷及其潜在直接靶点的临床疗效。
