Sickle-Santanello B J, Farrar W B, Dobson J L, O'Toole R V, Keyhani-Rofagha S
Am J Surg. 1986 Oct;152(4):393-5. doi: 10.1016/0002-9610(86)90310-7.
The mortality of squamous cell carcinoma of the tongue has not significantly improved in decades. Much of the information that has been gathered to date has been based on retrospective analyses. There is little consensus on treatment of the disease. In an attempt to define an objective prognostic indicator of aggressiveness of these tumors, a retrospective analysis of 15 paraffin-embedded specimens using flow cytometry was performed. Ten patients (67 percent) had aneuploid tumors and had a 5 year disease-free survival rate of 33 percent, whereas patients with diploid tumors (33 percent) had a 5 year disease-free survival rate of 80 percent. Although the number of patients was small, it appears that flow cytometry may be an objective prognostic indicator in patients with squamous cell carcinoma of the tongue. Larger series of archival paraffin-embedded flow cytometry analyses are recommended, as well as examination of variables other than the disease-free survival rate.
几十年来，舌鳞状细胞癌的死亡率并无显著改善。迄今为止收集到的大部分信息都是基于回顾性分析。对于该疾病的治疗，几乎没有达成共识。为了确定这些肿瘤侵袭性的客观预后指标，对15份石蜡包埋标本进行了流式细胞术回顾性分析。10例患者（67%）患有非整倍体肿瘤，其5年无病生存率为33%，而患有二倍体肿瘤的患者（33%）5年无病生存率为80%。尽管患者数量较少，但流式细胞术似乎可能是舌鳞状细胞癌患者的客观预后指标。建议进行更大规模的存档石蜡包埋流式细胞术分析系列研究，以及对无病生存率以外的变量进行检查。
