Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Nat Commun. 2023 Sep 5;14(1):5417. doi: 10.1038/s41467-023-41132-w.
Cell lines are valuable resources as model for human biology and translational medicine. It is thus important to explore the concordance between the expression in various cell lines vis-à-vis human native and disease tissues. In this study, we investigate the expression of all human protein-coding genes in more than 1,000 human cell lines representing 27 cancer types by a genome-wide transcriptomics analysis. The cell line gene expression is compared with the corresponding profiles in various tissues, organs, single-cell types and cancers. Here, we present the expression for each cell line and give guidance for the most appropriate cell line for a given experimental study. In addition, we explore the cancer-related pathway and cytokine activity of the cell lines to aid human biology studies and drug development projects. All data are presented in an open access cell line section of the Human Protein Atlas to facilitate the exploration of all human protein-coding genes across these cell lines.
细胞系是研究人类生物学和转化医学的重要资源。因此，探索各种细胞系与人类天然组织和疾病组织之间的表达一致性非常重要。在这项研究中，我们通过全基因组转录组学分析研究了 1000 多种代表 27 种癌症类型的人类细胞系中所有人类蛋白编码基因的表达。将细胞系基因表达与各种组织、器官、单细胞类型和癌症中的相应谱进行比较。在这里，我们为每个细胞系提供表达谱，并为给定的实验研究提供最合适的细胞系指导。此外，我们还研究了细胞系的癌症相关途径和细胞因子活性，以帮助人类生物学研究和药物开发项目。所有数据都在人类蛋白质图谱的开放获取细胞系部分中呈现，以促进对这些细胞系中所有人类蛋白编码基因的探索。
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