Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan.
Department of Physical Chemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki City, Osaka, 569-1094, Japan.
J Antibiot (Tokyo). 2023 Nov;76(11):673-677. doi: 10.1038/s41429-023-00652-9. Epub 2023 Sep 5.
Botryorhodines K (1) and L (2), two new depsidone derivatives, along with one known metabolite, 4-O-demethylbarbatic acid (3), were isolated from the culture extract of a fungus of the genus Arcopilus. The structures of 1‒3 were determined by the analysis of NMR and MS spectral data and the absolute configuration of 1 was established by single-crystal X-ray diffraction analysis. Compounds 1 and 2 showed antimicrobial activity against Gram-positive bacteria and cytotoxicity against murine leukemia P388 cells.
博特罗红菌素 K（1）和 L（2），两种新的去甲鞣花酸衍生物，以及一种已知的代谢产物 4-O-去甲巴马丁酸（3），从真菌属 Arcopilus 的培养提取物中分离得到。通过分析 NMR 和 MS 光谱数据确定了 1-3 的结构，通过单晶 X 射线衍射分析确定了 1 的绝对构型。化合物 1 和 2 对革兰氏阳性菌表现出抗菌活性，对小鼠白血病 P388 细胞表现出细胞毒性。
