Rohrer L, Winterhalter K H, Eckert J, Köhler P
Antimicrob Agents Chemother. 1986 Aug;30(2):254-7. doi: 10.1128/AAC.30.2.254.
Giardia lamblia trophozoites were killed in vitro by 1% fresh human milk in the presence of bile. A similar effect was achieved in the absence of bile with milk which had been stored for at least 24 h at 6 degrees C. This killing activity was found to be caused by unsaturated fatty acids. Depending on their chain length and the number of double bonds, the concentrations of unsaturated fatty acids required for a 50% killing effect varied between 15 and 36 microM. The saturated palmitic and stearic acids, as well as various substances related to fatty acids, showed only a slight killing effect. Bile enhanced and serum suppressed the action of fatty acids on the protozoan parasite. The possible site of interference of unsaturated fatty acids within G. lamblia and the reasons for the obvious inefficacy of dietary fatty acids in giardiasis are discussed.
在胆汁存在的情况下，1%的新鲜人乳可在体外杀死贾第虫滋养体。在6摄氏度下储存至少24小时的牛奶，在无胆汁的情况下也能产生类似效果。发现这种杀伤活性是由不饱和脂肪酸引起的。根据其链长和双键数量，产生50%杀伤效果所需的不饱和脂肪酸浓度在15至36微摩尔之间。饱和棕榈酸和硬脂酸以及与脂肪酸相关的各种物质仅表现出轻微的杀伤作用。胆汁增强而血清抑制脂肪酸对原生动物寄生虫的作用。文中讨论了不饱和脂肪酸在贾第虫体内可能的干扰位点以及饮食脂肪酸在贾第虫病中明显无效的原因。
