幽门弯曲菌对三种大环内酯类抗生素（红霉素、罗红霉素[RU 28965]和CP 62993）及利福平的敏感性。
Susceptibility of Campylobacter pyloridis to three macrolide antibiotics (erythromycin, roxithromycin [RU 28965], and CP 62,993) and rifampin.
作者信息
Czinn S, Carr H, Aronoff S
出版信息
Antimicrob Agents Chemother. 1986 Aug;30(2):328-9. doi: 10.1128/AAC.30.2.328.
Abstract
The presence of Campylobacter pyloridis in the gastric mucosa was recently linked to peptic ulcer disease. This study compared the inhibitory activity of three macrolide compounds (erythromycin, roxithromycin [RU 28965], and CP 62,993) and rifampin against 10 clinical isolates of C. pyloridis. The macrolides were equally effective against the test strains, with MICs ranging from 0.06 to 0.5 microgram/ml; rifampin was less active, with MICs ranging from 0.25 to greater than 1 microgram/ml. Erythromycin and the two new macrolide derivatives are potentially useful agents in the treatment of infections caused by C. pyloridis.
摘要
胃黏膜中幽门弯曲菌的存在最近被认为与消化性溃疡病有关。本研究比较了三种大环内酯类化合物（红霉素、罗红霉素[RU 28965]和CP 62993）及利福平对10株幽门弯曲菌临床分离株的抑制活性。大环内酯类化合物对测试菌株的效果相同，其最低抑菌浓度（MIC）范围为0.06至0.5微克/毫升；利福平活性较低，MIC范围为0.25至大于1微克/毫升。红霉素及两种新的大环内酯衍生物可能是治疗幽门弯曲菌感染的有效药物。
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