Rose D P, Boyar A P, Wynder E L
Cancer. 1986 Dec 1;58(11):2363-71. doi: 10.1002/1097-0142(19861201)58:11<2363::aid-cncr2820581102>3.0.co;2-#.
The 1978-1979 mortality rates for cancers of the breast, prostate, ovary, and colon in 26 to 30 countries were related to the average 1979-1981 food availability data published by the United Nations. The previously described relationship between breast cancer mortality rates and animal fat consumption continues to be evident, and applies also to the other three tumor types. The correlation with breast cancer was particularly strong in postmenopausal women. Since 1964, particularly notable increases in both breast cancer mortality rate and dietary fat intake have occurred in those countries with a relatively low breast cancer risk. The international comparisons support evidence from animal experiments that diets in which olive oil is a major source of fat are associated with reduced breast cancer risk. The excess in mortality rates for breast and ovarian cancer in Israel relative to the national animal fat consumption may be due to the mixed ethnic origin of the Israeli population. Positive correlations between foods and cancer mortality rates were particularly strong in the case of meats and milk for breast cancer, milk for prostate and ovarian cancer, and meats for colon cancer. All four tumor types showed a negative correlation with cereal intake, which was particularly strong in the case of prostate and ovarian cancer. Although, in general, there was a good positive correlation between prostate and breast cancer mortality rates and between prostate cancer and animal fat, discrepancies in national ranking indicate the operation of other etiologic factors that modify risk. The observed positive correlations between the four cancer mortality rates and caloric intake from animal sources, but negative correlations for vegetable-derived calories, suggest that, of the two, animal fat and not energy is the major dietary influence on cancer risk.
1978 - 1979年，26至30个国家的乳腺癌、前列腺癌、卵巢癌和结肠癌死亡率与联合国公布的1979 - 1981年食物平均可获得量数据相关。先前描述的乳腺癌死亡率与动物脂肪消费之间的关系仍然明显，并且也适用于其他三种肿瘤类型。绝经后女性中与乳腺癌的相关性尤为强烈。自1964年以来，在乳腺癌风险相对较低的国家，乳腺癌死亡率和膳食脂肪摄入量都出现了特别显著的增加。国际比较支持动物实验的证据，即橄榄油是主要脂肪来源的饮食与降低乳腺癌风险相关。以色列乳腺癌和卵巢癌死亡率相对于全国动物脂肪消费量过高，可能是由于以色列人口的混合种族起源。食物与癌症死亡率之间的正相关在乳腺癌的肉类和牛奶、前列腺癌和卵巢癌的牛奶以及结肠癌的肉类方面尤为强烈。所有四种肿瘤类型都与谷物摄入量呈负相关，在前列腺癌和卵巢癌方面尤为强烈。虽然一般来说，前列腺癌和乳腺癌死亡率之间以及前列腺癌和动物脂肪之间存在良好的正相关，但国家排名的差异表明存在其他改变风险的病因因素。观察到的四种癌症死亡率与动物源热量摄入之间的正相关，但与植物源热量呈负相关，表明在这两者中，动物脂肪而非能量是对癌症风险的主要饮食影响因素。
