Department and Clinic of Dermatology, Venereology and Allergology, Wroclaw Medical University, Poland.
Department and Clinic of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Poland.
Biomed Res Int. 2019 Jan 13;2019:7304345. doi: 10.1155/2019/7304345. eCollection 2019.
Psoriasis is often accompanied by obesity, hyperlipidemia, diabetes, and metabolic syndrome as risk factors of cardiovascular conditions and premature mortality.
The study was aimed at investigating whether psoriatic patients, who carry risk allele of obesity-related gene, are more predisposed to obesity and metabolic disturbances and whether it influences the severity of psoriasis.
197 patients with psoriasis, representing Lower Silesia region of Poland, underwent physical examination and anthropometric measurements. Blood samples for biochemical and genetic analysis were collected. All patients were genotyped for gene rs9939609 variant. Identification of SNP was conducted with the use of minisequencing method.
Around 63% of patients were carriers of at least one risk allele A and 20% were AA homozygotes. The A allele was associated with increased BMI and hip and waist circumferences. The carriers of risk allele had increased PASI and CRP values and tended to have an increased insulin concentration.
Psoriatic patients, carriers of risk allele of gene rs9939609, have an increased risk for more severe psoriasis and obesity and may develop obesity-induced insulin resistance.
银屑病常伴有肥胖、高血脂、糖尿病和代谢综合征等心血管疾病和早逝的危险因素。
本研究旨在探讨银屑病患者携带肥胖相关基因的风险等位基因是否更容易肥胖和代谢紊乱，以及这是否会影响银屑病的严重程度。
197 名来自波兰下西里西亚地区的银屑病患者接受了体检和人体测量。采集血液样本进行生化和基因分析。所有患者均对基因 rs9939609 变体进行了基因分型。使用小测序法进行 SNP 的鉴定。
约 63%的患者至少携带一个风险等位基因 A，20%为 AA 纯合子。A 等位基因与 BMI、臀围和腰围增加有关。携带风险等位基因的患者 PASI 和 CRP 值升高，且胰岛素浓度有升高趋势。
携带基因 rs9939609 风险等位基因的银屑病患者发生更严重银屑病和肥胖的风险增加，并且可能发生肥胖诱导的胰岛素抵抗。
