Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences,Tehran, 1985717413, Iran.
Maragheh University of Medical Sciences,Maragheh, 9415969788,Iran.
Br J Nutr. 2019 Jun;121(11):1247-1254. doi: 10.1017/S0007114519000643. Epub 2019 Apr 1.
The present study investigated whether dietary patterns could interact with fat mass and obesity-associated (FTO) polymorphisms in relation to changes in BMI and waist circumference (WC) over 3⋅6 years of follow-up. Subjects were selected from participants of the Tehran Lipid and Glucose Study (n 4292, 43⋅2 % male). Dietary data were collected using a valid and reliable FFQ. Dietary patterns were determined using factor analysis. The genotypes of polymorphisms (rs1421085, rs1121980, rs17817449, rs8050136, rs9939973 and rs3751812) were determined. Genetic risk score (GRS) was calculated using the weighted method. Mean ages of men and women were 42·6 (sd 14) and 40⋅4 (sd 13) years, respectively. The healthy (e.g. vegetables and fruits) and the Western dietary patterns (WDP; e.g. soft drinks and fast foods) were extracted. In carriers of the risk alleles rs1121980, rs1421085, rs8050136, rs1781799 and rs3751812, BMI was approximately 2-fold higher in individuals in the higher quartile of WDP score, compared with the first quartile (P < 0⋅05). WC increased with increasing WDP score in carriers of the risk alleles rs1121980 and rs3751812, but not in individuals who did not carry any risk alleles. BMI and WC increased to a greater extent in the high GRS group while increasing quartiles of the WDP score, compared with the low GRS group (BMI change; Q1: 1⋅04 (se 0⋅34) v. Q4: 2⋅26 (se 0⋅36)) (WC change; Q1: 0⋅47 (se 0⋅32) v. Q4: 0⋅95 (se 0⋅34)) (P interaction < 0⋅05). These results suggest that adults with higher genetic predisposition to obesity are more susceptible to the harmful effects of adherence to the WDP, which emphasised the need to reduce the consumption of unhealthy foods for the prevention of obesity.
本研究旨在探讨饮食模式是否会与脂肪质量和肥胖相关（FTO）多态性相互作用，从而影响 BMI 和腰围（WC）在 3.6 年随访期间的变化。研究对象选自德黑兰血脂和血糖研究（n=4292，43.2%为男性）的参与者。采用有效可靠的 FFQ 收集饮食数据。采用因子分析确定饮食模式。多态性（rs1421085、rs1121980、rs17817449、rs8050136、rs9939973 和 rs3751812）的基因型通过聚合酶链式反应确定。使用加权法计算遗传风险评分（GRS）。男性和女性的平均年龄分别为 42.6（sd 14）岁和 40.4（sd 13）岁。提取了健康（如蔬菜和水果）和西方饮食模式（WDP；如软饮料和快餐）。在风险等位基因 rs1121980、rs1421085、rs8050136、rs1781799 和 rs3751812 的携带者中，与 WDP 评分第一四分位相比，WDP 评分较高的个体 BMI 约高 2 倍（P < 0.05）。在携带风险等位基因 rs1121980 和 rs3751812 的个体中，WC 随 WDP 评分的增加而增加，但在未携带任何风险等位基因的个体中则没有这种情况。与低 GRS 组相比，高 GRS 组在 WDP 评分增加的四分位数时，BMI 和 WC 的增加幅度更大（BMI 变化；Q1：1.04（se 0.34）v. Q4：2.26（se 0.36））（WC 变化；Q1：0.47（se 0.32）v. Q4：0.95（se 0.34））（P 交互 < 0.05）。这些结果表明，具有更高肥胖遗传易感性的成年人更容易受到坚持 WDP 的有害影响，这强调了为预防肥胖减少食用不健康食物的必要性。
