Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Front Immunol. 2023 Aug 31;14:1241262. doi: 10.3389/fimmu.2023.1241262. eCollection 2023.
Inflammatory bowel disease (IBD), a general term encompassing Crohn's disease (CD) and ulcerative colitis (UC), and other conditions, is a chronic and relapsing autoimmune disease that can occur in any part of the digestive tract. While the cause of IBD remains unclear, it is acknowledged that the disease has much to do with the dysregulation of intestinal immunity. In the intestinal immune regulatory system, Cholesterol-25-hydroxylase (CH25H) plays an important role in regulating the function of immune cells and lipid metabolism through catalyzing the oxidation of cholesterol into 25-hydroxycholesterol (25-HC). Specifically, CH25H focuses its mechanism of regulating the inflammatory response, signal transduction and cell migration on various types of immune cells by binding to relevant receptors, and the mechanism of regulating lipid metabolism and immune cell function via the transcription factor Sterol Regulator-Binding Protein. Based on this foundation, this article will review the function of CH25H in intestinal immunity, aiming to provide evidence for supporting the discovery of early diagnostic and treatment targets for IBD.
炎症性肠病（IBD）是一个涵盖克罗恩病（CD）和溃疡性结肠炎（UC）及其他疾病的术语，是一种可发生于消化道任何部位的慢性、复发性自身免疫性疾病。虽然 IBD 的病因仍不清楚，但人们普遍认为该病与肠道免疫失调有很大关系。在肠道免疫调节系统中，胆固醇-25-羟化酶（CH25H）通过催化胆固醇氧化为 25-羟胆固醇（25-HC），在调节免疫细胞功能和脂质代谢方面发挥重要作用。具体而言，CH25H 通过与相关受体结合，将其调节炎症反应、信号转导和细胞迁移的机制集中在各种类型的免疫细胞上，并通过转录因子甾醇调节结合蛋白调节脂质代谢和免疫细胞功能的机制。基于此，本文将综述 CH25H 在肠道免疫中的作用，旨在为发现 IBD 的早期诊断和治疗靶点提供依据。
