Goren T, Fischer D G, Rubinstein M
J Interferon Res. 1986 Aug;6(4):323-9. doi: 10.1089/jir.1986.6.323.
alpha-Interferon (IFN-alpha) was produced by either peripheral blood lymphocytes or by monocytes and purified by an anti-IFN-alpha affinity column. When these preparations were analyzed by reversed-phase HPLC, a difference in the distribution of IFN-alpha subtypes from the two cell types was found. While the two major subtypes of IFN from induced lymphocytes had apparent molecular weights of 20K and 21K, monocytes produce an additional subtype of molecular weight 26K in large quantities (50%). This subtype had greater activity on human cells than on bovine cells in comparison to other IFN-alpha subtypes.
α-干扰素（IFN-α）由外周血淋巴细胞或单核细胞产生，并通过抗IFN-α亲和柱进行纯化。当通过反相高效液相色谱法分析这些制剂时，发现来自两种细胞类型的IFN-α亚型分布存在差异。诱导淋巴细胞产生的两种主要IFN亚型的表观分子量分别为20K和21K，而单核细胞大量产生（50%）另一种分子量为26K的亚型。与其他IFN-α亚型相比，该亚型对人细胞的活性比对牛细胞的活性更高。
