Yang Jingpeng, Meng Lingtong, Li Yanan, Huang He
School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Qixia District, Nanjing, China.
Food Funct. 2023 Oct 2;14(19):8711-8733. doi: 10.1039/d3fo02110f.
The vital role of probiotics in the food field has been widely recognized, and at the same time, probiotics are gradually exhibiting surprising effects in the field of nutraceuticals, especially in regulating gut inflammation and the nutritional environment. As a dietary supplement in clinical nutrition, the coadministration of probiotics with antibiotics model has been applied to prevent intestinal infections caused by . However, the mechanism behind this "bacteria-drug combination" model remains unclear. In particular, the selection of specific probiotic strains, the order of probiotics or antibiotics, and the time interval of coadministration are key issues that need to be further explored and clarified. Here, we focus on the issues mentioned above and give reasonable opinions, mainly including: (1) probiotics are safer and more effective when they intervene after antibiotics have been used; (2) the choice of the time interval between coadministration should be based on the metabolism of antibiotics in the host, differences in probiotic strains, the baseline ecological environment of the host's intestine, and the host immune level; in addition, the selection of the coadministration regime should also take into account factors such as the antibiotic sensitivity of probiotics and dosage of probiotics; and (3) by encapsulating probiotics, combining probiotics with prebiotics, and developing next-generation probiotics (NGPs) and postbiotic formulations, we can provide a more reasonable reference for this type of "bacteria-drug combination" model, and also provide targeted guidance for the application of probiotic dietary supplements in the antibiotic management of infection.
益生菌在食品领域的重要作用已得到广泛认可，与此同时，益生菌在营养保健品领域也逐渐展现出惊人的效果，尤其是在调节肠道炎症和营养环境方面。作为临床营养中的膳食补充剂，益生菌与抗生素联合使用的模式已被应用于预防由……引起的肠道感染。然而，这种“菌药组合”模式背后的机制仍不清楚。特别是，特定益生菌菌株的选择、益生菌或抗生素的使用顺序以及联合给药的时间间隔是需要进一步探索和明确的关键问题。在此，我们聚焦上述问题并给出合理建议，主要包括：（1）在使用抗生素后使用益生菌进行干预更安全、有效；（2）联合给药时间间隔的选择应基于抗生素在宿主体内的代谢、益生菌菌株差异、宿主肠道的基线生态环境以及宿主免疫水平；此外，联合给药方案的选择还应考虑益生菌的抗生素敏感性和益生菌剂量等因素；（3）通过对益生菌进行包封、将益生菌与益生元结合以及开发下一代益生菌（NGPs）和后生元制剂，可为这种“菌药组合”模式提供更合理的参考，也可为益生菌膳食补充剂在感染的抗生素管理中的应用提供针对性指导。
