Department of Dental Science, Faculty of graduate studies, Arab American University, Ramallah, Palestine.
Department of Medicine, Al-Quds University, Abu Dis, Palestine.
BMC Oral Health. 2023 Sep 19;23(1):677. doi: 10.1186/s12903-023-03400-5.
Platelet-rich fibrin (PRF) is commonly used for ridge preservation following tooth extraction. However, its effectiveness diminishes over a period of two weeks as it is resorbed and loses its biological activities. Therefore, this clinical study aims to evaluate the effect of recurrent application of concentrated PRF (C-PRF) inside the extraction socket on the hard and soft tissue alterations.
Twenty patients requiring single tooth extraction and replacement with a dental implant were randomized into one of two ridge preservation approaches: Advanced PRF plus alone (Control group) or advanced PRF plus with the recurrent application of a C-PRF inside the socket every two weeks for 2 months (four times). The ridge width, the ridge height, and the soft tissue thickness were assessed clinically at the baseline and reassessed after 3 months from tooth extraction during implant surgery. Then the amount of hard tissue loss and soft tissue alterations were calculated.
There was a statistically significant difference in the amount of hard tissue loss between groups in the third month. The amount of horizontal ridge loss for the control and test groups were 2.9 ± 0.7 mm and 1.9 ± 0.5 mm, respectively (p-value < 0.05). The vertical bone loss for control and test groups were 1.8 ± 0.5 mm and 1.0 ± 0.3 mm, respectively (p-value < 0.05). Additionally, for the soft tissue thickness, there was no statistical difference between the groups (p-value > 0.05).
Within the limitations of this study, the recurrent application of C-PRF in the extraction socket could decrease the amount of ridge alteration following tooth extraction and may play a role in the bone regeneration procedures.
Registered on ClinicalTrials.gov (ID: NCT05492357, on 08/08/2022).
富血小板纤维蛋白（PRF）常用于拔牙后的牙槽嵴保存。然而，它在两周内会被吸收，失去生物活性，因此其有效性会降低。因此，本临床研究旨在评估在拔牙窝内反复应用浓缩富血小板纤维蛋白（C-PRF）对硬组织和软组织变化的影响。
20 名需要单颗牙齿拔除并植入牙种植体的患者被随机分为两种牙槽嵴保存方法之一：高级 PRF 加单独应用（对照组）或高级 PRF 加每两周在拔牙窝内反复应用 C-PRF（共 4 次）。在拔牙后 3 个月进行种植手术时，临床评估牙槽嵴宽度、牙槽嵴高度和软组织厚度，并在基线时进行评估。然后计算硬组织损失和软组织变化的量。
在第 3 个月，两组之间的硬组织损失量有统计学差异。对照组和实验组的水平牙槽嵴损失量分别为 2.9±0.7mm 和 1.9±0.5mm（p 值<0.05）。对照组和实验组的垂直骨损失量分别为 1.8±0.5mm 和 1.0±0.3mm（p 值<0.05）。此外，两组间软组织厚度无统计学差异（p 值>0.05）。
在本研究的限制范围内，在拔牙窝内反复应用 C-PRF 可减少拔牙后牙槽嵴的改变量，并可能在骨再生过程中发挥作用。
ClinicalTrials.gov 注册（ID：NCT05492357，于 2022 年 8 月 8 日）。
