Giammarinaro Enrica, Baldini Nicola, Covani Ugo, Menini Maria, Pesce Paolo, Marconcini Simone
Research fellow at the Department of Surgical Sciences (DISC), University of Genova, Genoa, Italy.
Department of Biomedical and Medical Sciences, University of Siena, Viale Bracci, 16, Siena, 53100, Italy.
BMC Oral Health. 2025 Apr 22;25(1):615. doi: 10.1186/s12903-025-05922-6.
Improving soft tissue quality and quantity around dental implants is crucial for successful outcomes. Platelet-Rich Fibrin (PRF) is showing promise in enhancing wound healing and implant stability. This systematic review aims to evaluate the clinical benefits of PRF in soft tissue regeneration around dental implants compared to standard methods.
This systematic review adhered to the PRISMA guidelines and utilizing the PICO methodology, investigated the use of Platelet-Rich Fibrin (PRF) in soft tissue augmentation during implant therapy. The primary outcomes assessed include the width of keratinized mucosa and soft tissue thickness, comparing PRF interventions to standard techniques.The study included randomized controlled trials (RCTs) and comparative studies, focusing on human patients needing implant therapy with or without PRF. An extensive search of databases and manual references was conducted; data extraction involved assessing study quality and risk of bias, but due to high heterogeneity among studies, a meta-analysis was not feasible, leading to a systematic review of the available literature.
A total of 766 references were initially identified, with 29 being eligible after screening. Nine studies were included for detailed review. The findings revealed that PRF is effective in increasing the width of keratinized mucosa (KT) and soft tissue thickness (STT) around implants. Even if free gingival grafts (FGG) sometimes performed better. However, the differences between PRF and FGG were not clinically significant, and PRF offers lower cost, ease of use, and reduced morbidity. There was limited information on the esthetic outcomes of PRF, with only two studies addressing this aspect, showing mixed results.
Overall, PRF demonstrated positive effects on KT width and STT, but further research with rigorous methodology and larger sample sizes is needed to better understand its impact on implants health and esthetics.
改善牙种植体周围软组织的质量和数量对于取得成功的治疗效果至关重要。富血小板纤维蛋白（PRF）在促进伤口愈合和种植体稳定性方面显示出前景。本系统评价旨在评估与标准方法相比，PRF在牙种植体周围软组织再生中的临床益处。
本系统评价遵循PRISMA指南并采用PICO方法，研究了富血小板纤维蛋白（PRF）在种植治疗期间软组织增量中的应用。评估的主要结果包括角化黏膜宽度和软组织厚度，将PRF干预措施与标准技术进行比较。该研究纳入了随机对照试验（RCT）和比较研究，重点关注需要进行种植治疗的人类患者，无论是否使用PRF。对数据库和手动参考文献进行了广泛检索；数据提取涉及评估研究质量和偏倚风险，但由于研究之间存在高度异质性，无法进行荟萃分析，因此对现有文献进行了系统评价。
最初共识别出766篇参考文献，筛选后有29篇符合条件。纳入9项研究进行详细审查。结果显示，PRF可有效增加种植体周围角化黏膜（KT）的宽度和软组织厚度（STT）。即使游离龈移植（FGG）有时表现更好。然而，PRF与FGG之间的差异在临床上并不显著，并且PRF成本更低、使用方便且发病率更低。关于PRF美学效果的信息有限，只有两项研究涉及这方面，结果不一。
总体而言，PRF对KT宽度和STT显示出积极影响，但需要采用更严谨的方法和更大样本量进行进一步研究，以更好地了解其对种植体健康和美学的影响。
