Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Eur Thyroid J. 2023 Nov 3;12(6). doi: 10.1530/ETJ-23-0168. Print 2023 Dec 1.
Given the high prevalence of thyroid nodules and the potential for malignancy, it is imperative to understand the various factors that contribute to their development. This study aimed to explore the relationship between metabolic syndrome, lifestyle, and thyroid nodules in adult men in southern China.
This study enrolled a total of 183,990 subjects at a medical examination center in a general hospital in southern China between January 1, 2015, and December 31, 2020. Multivariate logistic regression analysis was utilized to evaluate the relationship between metabolic syndrome, lifestyle factors, and thyroid nodules. Furthermore, structural equation modeling elucidated the intricate relationships among these variables.
The prevalence of thyroid nodules among Chinese adult males was 14.9%. Several factors were identified as risk factors for thyroid nodules, including advanced age, irregular meal time, smoking or quitting smoking, quitting drinking, heavy manual labor, hypertension, diabetes, dyslipidemia and centripetal obesity, and those belonging to ethnic minorities and drinking alcohol were found to be protective factors against thyroid nodules. Structural equation modeling highlighted metabolic syndrome's mediating role amidst lifestyle influences on thyroid nodules.
The prevalence of thyroid nodules in Chinese adult males is relatively moderate to low. The factors identified in this study can help clinicians identify high-risk patients and develop targeted screening strategies for the timely detection of thyroid nodules. However, further mechanistic research and longitudinal studies are necessary to explore the underlying causes and establish causal relationships.
鉴于甲状腺结节的高发率和恶性肿瘤的潜在风险，了解导致其发生的各种因素至关重要。本研究旨在探讨代谢综合征、生活方式与中国南方成年男性甲状腺结节之间的关系。
本研究纳入了 2015 年 1 月 1 日至 2020 年 12 月 31 日期间在中国南方一家综合医院体检中心的 183990 名受试者。采用多变量逻辑回归分析评估代谢综合征、生活方式因素与甲状腺结节之间的关系。此外，结构方程模型阐明了这些变量之间的复杂关系。
中国成年男性甲状腺结节的患病率为 14.9%。几个因素被确定为甲状腺结节的危险因素，包括年龄较大、不规律的用餐时间、吸烟或戒烟、戒酒、重体力劳动、高血压、糖尿病、血脂异常和向心性肥胖，而属于少数民族和饮酒者则被认为是甲状腺结节的保护因素。结构方程模型突出了代谢综合征在生活方式对甲状腺结节影响中的中介作用。
中国成年男性甲状腺结节的患病率处于中等偏低水平。本研究中确定的因素有助于临床医生识别高危患者，并制定针对甲状腺结节的靶向筛查策略。然而，需要进一步的机制研究和纵向研究来探索其潜在原因并建立因果关系。
