Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Dis Model Mech. 2023 Oct 1;16(10). doi: 10.1242/dmm.050476. Epub 2023 Sep 20.
Ongoing global health challenges posed by emerging and re-emerging viruses have highlighted the critical importance of understanding virus-host interactions in countering these threats. Environmental changes, urbanisation and ecological disruption, coupled with the adaptable nature of viruses, facilitates the emergence and spread of new viruses. This Editorial emphasises the urgency of a concerted effort in understanding virus-host interactions to inform the development of therapeutics and vaccines, and help predict disease outcomes. Furthermore, efforts to monitor viral evolution, identify mutations of concern, and develop 'universal' vaccines and broad-spectrum antiviral drugs are needed to counter viral evolution and potentially prevent future viral emergences. Widespread public mistrust surrounding viruses and vaccines also calls for improvement in science communication. A 'One Health' approach that advocates the development of robust global health systems, interdisciplinary collaborations and equity in health access is therefore imperative for transforming the virology landscape.
新兴和重现的病毒对全球健康构成的持续挑战凸显了理解病毒-宿主相互作用对于应对这些威胁的重要性。环境变化、城市化和生态破坏，加上病毒的适应性，促进了新病毒的出现和传播。本社论强调了齐心协力理解病毒-宿主相互作用的紧迫性，以便为治疗方法和疫苗的开发提供信息，并帮助预测疾病结果。此外，还需要努力监测病毒的进化，识别令人关注的突变，并开发“通用”疫苗和广谱抗病毒药物，以对抗病毒的进化，并有可能预防未来的病毒出现。公众对病毒和疫苗的广泛不信任也要求改善科学传播。因此，倡导发展强大的全球卫生系统、跨学科合作和健康获取公平的“同一健康”方法对于改变病毒学格局至关重要。
