RANet: a custom CNN model and quanvolutional neural network for the automated detection of rheumatoid arthritis in hand thermal images.

Rheumatoid arthritis is an autoimmune disease which affects the small joints. Early prediction of RA is necessary for the treatment and management of the disease. The current work presents a deep learning and quantum computing-based automated diagnostic approach for RA in hand thermal imaging. The study's goals are (i) to develop a custom RANet model and compare its performance with the pretrained models and quanvolutional neural network (QNN) to distinguish between the healthy subjects and RA patients, (ii) To validate the performance of the custom model using feature selection method and classification using machine learning (ML) classifiers. The present study developed a custom RANet model and employed pre-trained models such as ResNet101V2, InceptionResNetV2, and DenseNet201 to classify the RA patients and normal subjects. The deep features extracted from the RA Net model are fed into the ML classifiers after the feature selection process. The RANet model, RA Net+ SVM, and QNN model produced an accuracy of 95%, 97% and 93.33% respectively in the classification of healthy groups and RA patients. The developed RANet and QNN models based on thermal imaging could be employed as an accurate automated diagnostic tool to differentiate between the RA and control groups.