Department of Innovative Visual Science (S.K., R.I.), Osaka University Graduate School of Medicine, Osaka, Japan; Department of Ophthalmology (S.K., R.M., A.M., S.A., S.M., K.N.), Osaka University Graduate School of Medicine, Osaka, Japan; SEED Co. (R.I.), Ltd., Tokyo, Japan; and Department of Orthoptics (T.M.), Faculty of Medical Technology, Teikyo University, Tokyo, Japan.
Eye Contact Lens. 2024 Jan 1;50(1):16-22. doi: 10.1097/ICL.0000000000001041. Epub 2023 Sep 21.
To characterize higher-order aberrations (HOAs) in different severities of keratoconus (KC) from the anterior and posterior corneal surfaces and whole eye using an integrated Scheimpflug corneal tomographer/Hartmann-Shack wavefront aberrometer.
This study included eyes with clinical KC, topographic KC (no clinical signs), fellow eyes with very asymmetric ectasia with normal topography and no clinical signs (VAE-NT), and control eyes. Corneal and ocular wavefront aberrations were obtained using an integrated Scheimpflug tomographer/Hartmann-Shack wavefront aberrometer. The diagnostic capability of distinguishing VAE-NT from the control was also tested.
This study included 68 eyes with clinical KC, 44 with topographic KC, 26 with VAE-NT, and 45 controls. Clinical KC had significantly greater total HOAs and coma from the anterior and posterior corneal surfaces and whole eye than the other groups ( P <0.05). Although topographic KC had significantly greater values in all wavefront parameters than the control ( P <0.05), ocular and corneal HOAs did not differ between the VAE-NT and control groups. The coma from the anterior cornea in topographic KC was significantly greater than that in VAE-NT ( P <0.05); the coma from the posterior cornea and whole eye did not differ. Total HOAs from the anterior corneal surface exhibited the highest area under the receiver operating characteristic curve value of 0.774 (sensitivity, 73%; specificity, 78%).
A comprehensive wavefront assessment can be used to quantitatively evaluate corneal and ocular HOAs across various severity of KC. Total HOAs from the anterior corneal surface exhibited the potential ability in distinguishing VAE-NT from the control eyes.
使用整合的 Scheimpflug 角膜断层扫描仪/哈特曼 - 夏克波前像差仪，从角膜前表面和后表面以及整个眼睛的角度描述不同严重程度的圆锥角膜（KC）的高阶像差（HOA）。
本研究纳入了临床 KC 眼、地形 KC（无临床体征）眼、伴有非常不对称扩张但具有正常地形且无临床体征的对侧眼（VAE-NT）和对照眼。使用整合的 Scheimpflug 断层扫描仪/哈特曼 - 夏克波前像差仪获取角膜和眼波前像差。还测试了区分 VAE-NT 与对照的诊断能力。
本研究纳入了 68 只临床 KC 眼、44 只地形 KC 眼、26 只 VAE-NT 眼和 45 只对照眼。临床 KC 的总 HOA 和角膜前表面和整个眼睛的彗差明显大于其他组（P <0.05）。尽管地形 KC 的所有波前参数值均明显大于对照组（P <0.05），但 VAE-NT 与对照组之间的眼和角膜 HOA 没有差异。地形 KC 的角膜前表面彗差明显大于 VAE-NT（P <0.05）；角膜后表面和整个眼睛的彗差没有差异。角膜前表面总 HOA 的受试者工作特征曲线下面积值最高，为 0.774（敏感性为 73%，特异性为 78%）。
全面的波前评估可用于定量评估各种严重程度 KC 的角膜和眼 HOA。角膜前表面总 HOA 具有从对照眼区分 VAE-NT 的潜在能力。
