Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan.
Cornea. 2021 Oct 1;40(10):1276-1281. doi: 10.1097/ICO.0000000000002631.
To evaluate the correlations between corneal biomechanical indices from dynamic Scheimpflug assessment and optical quality assessed as higher-order aberrations (HOAs) using a Hartmann-Shack ocular wavefront sensor in patients with keratoconus (KC).
In this prospective, observational case series, the eyes with KC or KC suspect (KCS) from Osaka University Hospital, Osaka, Japan, were analyzed. Corneal biomechanical assessment was performed using Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany), and ocular wavefront aberrations were measured using the KR-1W (Topcon Corp, Tokyo, Japan). Correlations between the biomechanical indices and ocular HOAs were assessed. Corneal biomechanical indices included the deformation amplitude ratio within 2 mm, integrated radius, stiffness parameter at the first applanation, and the linear Corvis Biomechanical Index. Wavefront data of the central 4-mm region were expanded up to the sixth order of Zernike polynomials. The magnitudes of trefoil, coma, tetrafoil, secondary astigmatism, and spherical aberration were calculated by Zernike vector analysis and then used as ocular HOA parameters along with total HOAs.
Thirty-four KC eyes and 37 KCS eyes were included. KC eyes showed significant correlations between ocular HOAs and biomechanics, whereas there were few significant correlations in KCS eyes. In KC eyes, deformation amplitude ratio within 2 mm, integrated radius, and Corvis Biomechanical Index beta showed stronger correlations with coma among the wavefront parameters.
Corneal biomechanical indices correlated with ocular HOAs in patients with KC. In particular, there was a strong association with the increase in coma caused by inferosuperior asymmetry of the shape of the cornea in patients with KC.
评估使用哈特曼-夏克眼波前传感器在圆锥角膜（KC）患者中动态 Scheimpflug 评估的角膜生物力学指标与高阶像差（HOA）之间的相关性。
本前瞻性观察性病例系列研究分析了来自日本大阪大学医院的 KC 或 KC 疑似（KCS）患者的眼睛。使用 Corvis ST（Oculus Optikgeräte GmbH，德国威茨拉尔）进行角膜生物力学评估，使用 KR-1W（Topcon 公司，日本东京）测量眼波前像差。评估了生物力学指标与眼 HOA 之间的相关性。角膜生物力学指标包括 2mm 内的变形幅度比、整合半径、第一次压平处的刚性参数和线性 Corvis 生物力学指数。中央 4mm 区域的波前数据扩展到第 6 阶泽尼克多项式。使用泽尼克矢量分析计算三叶形、彗差、四叶形、二次散光和球差的大小，然后将其用作眼 HOA 参数，以及总 HOA。
纳入 34 只 KC 眼和 37 只 KCS 眼。KC 眼的眼 HOA 与生物力学之间存在显著相关性，而 KCS 眼则很少有显著相关性。在 KC 眼中，2mm 内的变形幅度比、整合半径和 Corvis 生物力学指数β与前波阵面参数中的彗差具有更强的相关性。
角膜生物力学指标与 KC 患者的眼 HOA 相关。特别是，在 KC 患者中，角膜形状的下上不对称引起的彗差增加与角膜生物力学指标之间存在很强的关联。
