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用于 SpO 监测的柔性可穿戴全有机光体积描记传感器的最新进展。

Recent Progress in Flexible and Wearable All Organic Photoplethysmography Sensors for SpO Monitoring.

机构信息

Mines Saint-Étienne, Centre Microélectronique de Provence, Department of Flexible Electronics, 880, Avenue de Mimet, Gardanne, 13541, France.

出版信息

Adv Sci (Weinh). 2023 Nov;10(31):e2302752. doi: 10.1002/advs.202302752. Epub 2023 Sep 23.

Abstract

Flexible and wearable biosensors are the next-generation healthcare devices that can efficiently monitor human health conditions in day-to-day life. Moreover, the rapid growth and technological advancements in wearable optoelectronics have promoted the development of flexible organic photoplethysmography (PPG) biosensor systems that can be implanted directly onto the human body without any additional interface for efficient bio-signal monitoring. As an example, the pulse oximeter utilizes PPG signals to monitor the oxygen saturation (SpO ) in the blood volume using two distinct wavelengths with organic light emitting diode (OLED) as light source and an organic photodiode (OPD) as light sensor. Utilizing the flexible and soft properties of organic semiconductors, pulse oximeter can be both flexible and conformal when fabricated on thin polymeric substrates. It can also provide highly efficient human-machine interface systems that can allow for long-time biological integration and flawless measurement of signal data. In this work, a clear and systematic overview of the latest progress and updates in flexible and wearable all-organic pulse oximetry sensors for SpO monitoring, including design and geometry, processing techniques and materials, encapsulation and various factors affecting the device performance, and limitations are provided. Finally, some of the research challenges and future opportunities in the field are mentioned.

摘要

灵活可穿戴生物传感器是下一代医疗保健设备,可在日常生活中有效地监测人体健康状况。此外,可穿戴光电技术的快速发展促进了柔性有机光体积描记(PPG)生物传感器系统的发展,该系统可以直接植入人体,而无需任何额外的接口来进行有效的生物信号监测。例如,脉搏血氧计利用 PPG 信号,通过使用有机发光二极管 (OLED) 作为光源和有机光电二极管 (OPD) 作为光传感器的两个不同波长来监测血液容积中的氧饱和度 (SpO )。利用有机半导体的灵活和柔软特性,当在薄聚合物衬底上制造时,脉搏血氧计可以是灵活的和顺应的。它还可以提供高效的人机接口系统,允许长时间的生物集成和信号数据的完美测量。在这项工作中,提供了对用于 SpO 监测的灵活可穿戴全有机脉搏血氧计传感器的最新进展和更新的清晰和系统的概述,包括设计和几何形状、处理技术和材料、封装以及影响器件性能的各种因素和限制。最后,提到了该领域的一些研究挑战和未来机遇。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78fd/10625116/f46db22ff9af/ADVS-10-2302752-g015.jpg

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