Microbiota I-Center (MagIC), Hong Kong, Hong Kong SAR, China.
Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Front Cell Infect Microbiol. 2023 Sep 6;13:1249069. doi: 10.3389/fcimb.2023.1249069. eCollection 2023.
Emerging preclinical and clinical studies suggest that altered gut microbiome composition and functions are associated with coronavirus 2019 (COVID- 19) severity and its long-term complications. We hypothesize that COVID-19 outcome is associated with gut microbiome status in population-based settings.
Gut metagenomic data of the adult population consisting of 2871 subjects from 16 countries were obtained from ExperimentHub through R, while the dynamic death data of COVID-19 patients between January 22, 2020 and December 8, 2020 in each country was acquired from Johns Hopkins Coronavirus Resource Center. An adjusted stable mortality rate (SMR) was used to represent these countries' mortality and correlated with the mean relative abundance (mRA) of healthy adult gut microbiome species.
After excluding bacterial species with low prevalence (prevalence <0.2 in the included countries), the β-diversity was significantly higher in the countries with high SMR when compared with those with median or low SMR (p <0.001). We then identified the mRA of two butyrate producers, and , that were negatively correlated with SMR during the study period. And the reduction of these species was associated with severer COVID-19 manifestation.
Population-based microbiome signatures with the stable mortality rate of COVID-19 in different countries suggest that altered gut microbiome composition and functions are associated with mortality of COVID-19.
新兴的临床前和临床研究表明，肠道微生物组组成和功能的改变与 2019 年冠状病毒病（COVID-19）的严重程度及其长期并发症有关。我们假设 COVID-19 的结局与人群中肠道微生物组的状态有关。
通过 R，从 ExperimentHub 获取了由来自 16 个国家的 2871 名成年人组成的肠道宏基因组数据，同时从约翰霍普金斯冠状病毒资源中心获取了各国 COVID-19 患者在 2020 年 1 月 22 日至 12 月 8 日期间的动态死亡数据。采用调整后的稳定死亡率（SMR）来表示这些国家的死亡率，并与健康成年人肠道微生物组物种的平均相对丰度（mRA）相关联。
在排除流行率较低（在纳入的国家中流行率<0.2）的细菌物种后，高 SMR 国家的 β多样性明显高于中 SMR 或低 SMR 国家（p<0.001）。然后，我们确定了两种丁酸产生菌 和 的 mRA，在研究期间与 SMR 呈负相关。这些物种的减少与 COVID-19 表现更严重有关。
不同国家 COVID-19 稳定死亡率的基于人群的微生物组特征表明，肠道微生物组组成和功能的改变与 COVID-19 的死亡率有关。
