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来自马铃薯的四糖甾体糖苷生物碱对 和 马铃薯叶甲具有抗性。

Tetraose steroidal glycoalkaloids from potato provide resistance against and Colorado potato beetle.

机构信息

Wageningen University and Research, Wageningen, Netherlands.

出版信息

Elife. 2023 Sep 26;12:RP87135. doi: 10.7554/eLife.87135.

DOI:10.7554/eLife.87135
PMID:37751372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10522338/
Abstract

Plants with innate disease and pest resistance can contribute to more sustainable agriculture. Natural defence compounds produced by plants have the potential to provide a general protective effect against pathogens and pests, but they are not a primary target in resistance breeding. Here, we identified a wild relative of potato, , that provides us with unique insight in the role of glycoalkaloids in plant immunity. We cloned two atypical resistance genes that provide resistance to and Colorado potato beetle through the production of tetraose steroidal glycoalkaloids (SGA). Moreover, we provide in vitro evidence to show that these compounds have potential against a range of different (potato pathogenic) fungi. This research links structural variation in SGAs to resistance against potato diseases and pests. Further research on the biosynthesis of plant defence compounds in different tissues, their toxicity, and the mechanisms for detoxification, can aid the effective use of such compounds to improve sustainability of our food production.

摘要

具有先天抗病抗虫能力的植物有助于实现更可持续的农业。植物产生的天然防御化合物有可能对病原体和害虫提供普遍的保护作用，但它们不是抗病性育种的主要目标。在这里，我们鉴定了马铃薯的一种野生近缘种，为我们提供了糖基甾体生物碱 (SGA) 在植物免疫中的作用的独特见解。我们克隆了两个非典型的抗性基因，它们通过产生四糖甾体糖基生物碱 (SGA) 提供对 和科罗拉多马铃薯甲虫的抗性。此外，我们提供了体外证据表明，这些化合物对一系列不同的（马铃薯致病）真菌具有潜在的作用。这项研究将 SGA 的结构变异与马铃薯病虫害的抗性联系起来。进一步研究不同组织中植物防御化合物的生物合成、它们的毒性以及解毒机制，可以帮助有效利用这些化合物来提高我们食物生产的可持续性。

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