Nararak Jirod, Sanguanpong Unchalee, Sukkanon Chutipong, Manguin Sylvie, Chareonviriyaphap Theeraphap
Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand.
Association of Thai Innovation and Invention Promotion, Prachatipat 12130, Thailand.
Insects. 2023 Sep 20;14(9):773. doi: 10.3390/insects14090773.
Repellents play a major role in reducing the risk of mosquito-borne diseases by preventing mosquito bites. The present study evaluated the mosquito-repellent activity of β-caryophyllene oxide 1% (BCO), vetiver oil 2.5% (VO), and their binary mixtures (BCO + VO (1:1), BCO + VO (2:1), BCO + VO (1:2)) against four laboratory-colonized mosquito species, (L.), (Skuse), Theobald, and Say, using an excito-repellency assay system. In general, the compound mixtures produced a much stronger response in the mosquitoes than single compounds, regardless of the test conditions or species. The greatest synergetic effect was achieved with the combination of BCO + VO (1:2) in both contact and noncontact trials with (74.07-78.18%) and (55.36-83.64%). Knockdown responses to the binary mixture of BCO + VO were observed for , and , in the range of 18.18-33.33%. The synergistic repellent activity of BCO and VO used in this study may support increased opportunities to develop safer alternatives to synthetic repellents for personal protection against mosquitoes.
驱蚊剂通过防止蚊虫叮咬在降低蚊媒疾病风险方面发挥着重要作用。本研究使用兴奋驱避测定系统，评估了1%氧化石竹烯（BCO）、2.5%香根草油（VO）及其二元混合物（BCO + VO (1:1)、BCO + VO (2:1)、BCO + VO (1:2)）对四种实验室饲养的蚊虫种类，即致倦库蚊（Culex quinquefasciatus (L.)）、骚扰阿蚊（Armigeres subalbatus (Skuse)）、白纹伊蚊（Aedes albopictus Theobald）和埃及伊蚊（Aedes aegypti Say）的驱蚊活性。总体而言，无论测试条件或蚊虫种类如何，化合物混合物在蚊虫身上产生的反应都比单一化合物强烈得多。在与致倦库蚊（74.07 - 78.18%）和白纹伊蚊（55.36 - 83.64%）进行的接触和非接触试验中，BCO + VO (1:2)组合产生了最大的协同效应。观察到致倦库蚊、骚扰阿蚊和埃及伊蚊对BCO + VO二元混合物的击倒反应在18.18 - 33.33%范围内。本研究中使用的BCO和VO的协同驱蚊活性可能有助于增加开发更安全的合成驱蚊剂替代品用于个人防蚊的机会。
