Departamento de Biología, DCNE, Universidad de Guanajuato, Guanajuato C.P. 36050, Mexico.
Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo (UMSNH), Morelia C.P. 58030, Mexico.
Cells. 2023 Sep 8;12(18):2239. doi: 10.3390/cells12182239.
Fungal alcohol dehydrogenases (ADHs) participate in growth under aerobic or anaerobic conditions, morphogenetic processes, and pathogenesis of diverse fungal genera. These processes are associated with metabolic operation routes related to alcohol, aldehyde, and acid production. The number of ADH enzymes, their metabolic roles, and their functions vary within fungal species. The most studied ADHs are associated with ethanol metabolism, either as fermentative enzymes involved in the production of this alcohol or as oxidative enzymes necessary for the use of ethanol as a carbon source; other enzymes participate in survival under microaerobic conditions. The fast generation of data using genome sequencing provides an excellent opportunity to determine a correlation between the number of ADHs and fungal lifestyle. Therefore, this review aims to summarize the latest knowledge about the importance of ADH enzymes in the physiology and metabolism of fungal cells, as well as their structure, regulation, evolutionary relationships, and biotechnological potential.
真菌醇脱氢酶（ADH）参与需氧或厌氧条件下的生长、形态发生过程和多种真菌属的发病机制。这些过程与与酒精、醛和酸生产相关的代谢操作途径有关。ADH 酶的数量、其代谢作用及其功能在真菌种内有所不同。研究最多的 ADHs 与乙醇代谢有关，要么作为参与产生这种酒精的发酵酶，要么作为将乙醇用作碳源所必需的氧化酶；其他酶参与微需氧条件下的生存。使用基因组测序快速生成数据为确定 ADH 数量与真菌生活方式之间的相关性提供了极好的机会。因此，本综述旨在总结 ADH 酶在真菌细胞生理学和代谢中的重要性以及它们的结构、调节、进化关系和生物技术潜力的最新知识。
