Liu Chenning, Lai Wenyu, Zhao Meiduo, Zhang Yexuan, Hu Yuanjia
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR 999078, China.
Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Macao SAR 999078, China.
Antioxidants (Basel). 2023 Sep 8;12(9):1740. doi: 10.3390/antiox12091740.
The relationship between composite dietary antioxidant index (CDAI) levels and the risk of atherosclerotic cardiovascular disease (ASCVD) in postmenopausal women is unknown. In total, 3109 women from the National Health and Nutrition Examination Survey 2013-2018 were included in this cross-sectional study. We evaluated the association between CDAI levels and the risk of ASCVD by using three logistic regression models and restricted cubic splines. A stratified analysis and sensitivity analysis were also conducted. The restricted cubic splines exhibited an L-shaped dose-response association between CDAI levels and the ASCVD risk. Logistic regression analysis found that CDAI levels were negatively associated with the occurrence of ASCVD. The ORs associated with a per-SD increase in CDAI were 0.67 (95% CI: 0.51-0.88) for ASCVD risk. Similarly, women in the group with high CDAI levels were less likely to have ASCVD (OR = 0.71, 95% CI: 0.50-0.98) compared to those in the group with low CDAI levels. When the CDAI levels were divided into quartiles, it was found that the ORs for ASCVD with CDAI levels in Q2 (-1.04-1.11), Q3 (1.11-3.72), and Q4 (3.72-43.87) were 0.63 (0.44, 0.90), 0.64 (0.42, 0.94), and 0.51 (0.27, 0.97), respectively, compared to those with CDAI levels in Q1 (-6.83--1.04). In addition, age, high-density lipoprotein cholesterol levels, and smoking behaviors acted as potential modifiers, and ORs were more significant in women aged 40-69 years, in individuals with low high-density lipoprotein cholesterol levels, and in smokers ( for interaction <0.05). These findings may offer valuable insights into the role of CDAI levels in the development of ASCVD among postmenopausal women.
绝经后女性复合膳食抗氧化指数（CDAI）水平与动脉粥样硬化性心血管疾病（ASCVD）风险之间的关系尚不清楚。本横断面研究共纳入了2013 - 2018年美国国家健康与营养检查调查中的3109名女性。我们使用三个逻辑回归模型和受限立方样条评估了CDAI水平与ASCVD风险之间的关联。还进行了分层分析和敏感性分析。受限立方样条显示CDAI水平与ASCVD风险之间呈L形剂量反应关联。逻辑回归分析发现CDAI水平与ASCVD的发生呈负相关。CDAI每增加一个标准差，ASCVD风险的比值比（OR）为0.67（95%置信区间：0.51 - 0.88）。同样，与CDAI水平低的组相比，CDAI水平高的组女性患ASCVD的可能性较小（OR = 0.71，95%置信区间：0.50 - 0.98）。当将CDAI水平分为四分位数时，发现与第一四分位数（-6.83 - -1.04）的CDAI水平相比，第二四分位数（-1.04 - 1.11）、第三四分位数（1.11 - 3.72）和第四四分位数（3.72 - 43.87）的CDAI水平对应的ASCVD的OR分别为0.63（0.44，0.90）、0.64（0.42，0.94）和0.51（0.27，0.97）。此外，年龄、高密度脂蛋白胆固醇水平和吸烟行为是潜在的调节因素，在40 - 69岁的女性、高密度脂蛋白胆固醇水平低的个体和吸烟者中，OR更显著（交互作用P<0.05）。这些发现可能为CDAI水平在绝经后女性ASCVD发生中的作用提供有价值的见解。
