Almansour Ayidh M, Alhadlaq Meshari A, Alzahrani Khaloud O, Mukhtar Lenah E, Alharbi Abdulmohsen L, Alajel Sulaiman M
Molecular Biology Division, Reference Laboratory for Microbiology, Executive Department of Reference Laboratories, Research and Laboratories Sector, Saudi Food and Drug Authority (SFDA), Riyadh 11671, Saudi Arabia.
Antimicrobial Resistance Division, Reference Laboratory for Microbiology, Executive Department of Reference Laboratories, Research and Laboratories Sector, Saudi Food and Drug Authority (SFDA), Riyadh 11671, Saudi Arabia.
Microorganisms. 2023 Aug 22;11(9):2127. doi: 10.3390/microorganisms11092127.
The emergence of antimicrobial resistance (AMR) is a global health problem without geographic boundaries. This increases the risk of complications and, thus, makes it harder to treat infections, which can result in higher healthcare costs and a greater number of deaths. Antimicrobials are often used to treat infections from pathogens in food-producing animals, making them a potential source of AMR. Overuse and misuse of these drugs in animal agriculture can lead to the development of AMR bacteria, which can then be transmitted to humans through contaminated food or direct contact. It is therefore essential to take multifaceted, comprehensive, and integrated measures, following the One Health approach. To address this issue, many countries have implemented regulations to limit antimicrobial use. To our knowledge, there are previous studies based on AMR in food-producing animals; however, this paper adds novelty related to the AMR pathogens in livestock, as we include the recent publications of this field worldwide. In this work, we aim to describe the most critical and high-risk AMR pathogens among food-producing animals, as a worldwide health problem. We also focus on the dissemination of AMR genes in livestock, as well as its consequences in animals and humans, and future strategies to tackle this threat.
抗菌药物耐药性（AMR）的出现是一个无国界的全球卫生问题。这增加了并发症的风险，因此使得感染更难治疗，进而可能导致更高的医疗成本和更多的死亡人数。抗菌药物常用于治疗食用动物病原体引起的感染，使其成为AMR的一个潜在来源。在动物养殖业中过度使用和滥用这些药物会导致AMR细菌的产生，然后这些细菌可通过受污染的食物或直接接触传播给人类。因此，遵循“同一健康”方法采取多方面、全面和综合的措施至关重要。为解决这一问题，许多国家已实施法规来限制抗菌药物的使用。据我们所知，以前有基于食用动物AMR的研究；然而，本文增加了与家畜中AMR病原体相关的新颖内容，因为我们纳入了该领域全球范围内的最新出版物。在这项工作中，我们旨在将食用动物中最关键和高风险的AMR病原体描述为一个全球卫生问题。我们还关注AMR基因在家畜中的传播及其对动物和人类的影响，以及应对这一威胁的未来策略。
