Grail A, Norval M
Acta Obstet Gynecol Scand. 1986;65(5):443-7. doi: 10.3109/00016348609157381.
Serum copper and zinc levels were determined by atomic absorption spectroscopy in 110 women with varying degrees of cervical dysplasia up to carcinoma-in-situ and in 9 women with invasive carcinoma of the cervix, and compared with levels in 21 women with no evidence of cervical dysplasia. The average serum copper and zinc levels in the control group were 1.25 mg/l and 1.02 mg/l (respectively). The mean serum copper level increased with dysplasia to 1.4 mg/l and with invasive carcinoma to 1.47 mg/l. The mean serum zinc levels were decreased in cervical intra-epithelial neoplasia (CIN) grade 1 to 0.81 mg/l and in invasive carcinoma to 0.73 mg/l. The copper:zinc ratios varied significantly between controls, patients with cervical dysplasia and patients with invasive carcinoma (p less than 0.01). Measurement of serum ceruloplasmin revealed no significant differences among the control group and the groups of patients.
采用原子吸收光谱法测定了110例不同程度宫颈发育异常直至原位癌的女性以及9例宫颈浸润癌女性的血清铜和锌水平，并与21例无宫颈发育异常迹象的女性的水平进行了比较。对照组血清铜和锌的平均水平分别为1.25毫克/升和1.02毫克/升。随着发育异常程度的增加，血清铜平均水平升至1.4毫克/升，浸润癌时升至1.47毫克/升。宫颈上皮内瘤变（CIN）1级时血清锌平均水平降至0.81毫克/升，浸润癌时降至0.73毫克/升。对照组、宫颈发育异常患者和浸润癌患者之间的铜锌比值差异显著（p<0.01）。血清铜蓝蛋白的测定显示对照组与患者组之间无显著差异。
