Kim Soo Yeon, Kim Jae Wook, Ko Young Sook, Koo Jee Eun, Chung Hae Yeon, Lee-Kim Yang Cha
Department of Food and Nutrition, College of Human Ecology, Yonsei University, 134 Shinchon-dong, Sudaemun-ku, Seoul, Korea.
Nutr Cancer. 2003;47(2):126-30. doi: 10.1207/s15327914nc4702_3.
This study investigated serum lipid peroxidation, antioxidant capacity, and trace element levels in Korean women as related to uterine cervical neoplasia. Twenty-eight subjects had cervical intraepithelial neoplasia (CIN), 36 had invasive cervical cancer, as determined by a colposcopically directed biopsy, and controls included 44 subjects with normal colposcopic findings. Significantly lower selenium (Se) and zinc (Zn) levels and higher copper/Zn ratios were found in both CIN and cancer patients compared with the controls. Serum malondialdehyde levels decreased significantly in the order CIN>cancer>control, implying the involvement of reactive oxygen species at the precancerous stage, that is, prior to progression into invasive cervical cancer. Serum glutathione peroxidase activity was significantly lower in patients with CIN or cancer than controls, and total antioxidant ability decreased from controls to CIN to cancer (P < 0.0001). This study demonstrated the involvement of lipid peroxidation, decreased Se and Zn levels, and an impaired serum antioxidant system in the pathogenesis of cervical dysplasia. Further research is needed to examine the possibility of an effective chemopreventive treatment in cervical cancer based on enhancing the endogenous antioxidant system.
本研究调查了韩国女性血清脂质过氧化、抗氧化能力及微量元素水平与子宫颈肿瘤形成的关系。通过阴道镜引导下活检确定，28名受试者患有宫颈上皮内瘤变（CIN），36名患有浸润性宫颈癌，对照组包括44名阴道镜检查结果正常的受试者。与对照组相比，CIN患者和癌症患者的硒（Se）和锌（Zn）水平显著降低，铜/锌比值升高。血清丙二醛水平按CIN>癌症>对照组的顺序显著降低，这意味着活性氧在癌前阶段即进展为浸润性宫颈癌之前就已参与其中。CIN或癌症患者的血清谷胱甘肽过氧化物酶活性显著低于对照组，总抗氧化能力从对照组到CIN再到癌症患者逐渐降低（P < 0.0001）。本研究表明脂质过氧化、Se和Zn水平降低以及血清抗氧化系统受损参与了宫颈发育异常的发病机制。需要进一步研究以探讨基于增强内源性抗氧化系统进行宫颈癌有效化学预防治疗的可能性。
