• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

不同食用浆果中富含花青素提取物的鉴定、定量及抗抑郁样评估。

Identification, quantification, and antidepressant-like evaluation of anthocyanin-rich extracts from different dietary berries.

作者信息

Wang Jun, Cheng Jie, Zhu Ji-Xiao, Xu Guang-Hui, Huang Wei-Feng, Yi Li-Tao

机构信息

Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering Huaqiao University Xiamen People's Republic of China.

Research Center of Traditional Chinese Medicine Resources and Ethnic Medicine Jiangxi University of Chinese Medicine Nanchang People's Republic of China.

出版信息

Food Sci Nutr. 2024 Jun 14;12(9):6315-6327. doi: 10.1002/fsn3.4280. eCollection 2024 Sep.

DOI:10.1002/fsn3.4280
PMID:39554328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11561776/
Abstract

Berries are highly valued for their rich phenolic content, particularly anthocyanins, which are known for their antioxidative properties and potential effectiveness against depression. This study identified and quantified anthocyanin profiles in blueberry, blackberry, black mulberry, and cranberry using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS), followed by in vivo evaluation of their antidepressant-like activities. Blueberry and black mulberry showed significant levels of cyanidin-3-galactoside and cyanidin. Acute supplementation with these berries decreased serum corticosterone levels and increased monoamine neurotransmitters, while chronic supplementation enhanced antioxidative activity and reduced neuroinflammation in the hippocampus of mice. These findings indicate that the neurochemical, antioxidative, and anti-inflammatory effects of blueberry and black mulberry mediate their therapeutic role against depression. Berries rich in cyanidin-3-galactoside and cyanidin may be valuable in developing functional foods, dietary supplements, and pharmacological formulations for mental health improvement.

摘要

浆果因其丰富的酚类物质含量，尤其是花青素而备受重视，花青素以其抗氧化特性以及对抑郁症的潜在疗效而闻名。本研究使用超高效液相色谱 - 质谱联用仪（UPLC-MS）鉴定并定量了蓝莓、黑莓、黑桑椹和蔓越莓中的花青素谱，随后对它们的抗抑郁样活性进行了体内评估。蓝莓和黑桑椹显示出较高水平的矢车菊素 - 3 - 半乳糖苷和矢车菊素。急性补充这些浆果可降低血清皮质酮水平并增加单胺神经递质，而长期补充则增强了抗氧化活性并减轻了小鼠海马体中的神经炎症。这些发现表明，蓝莓和黑桑椹的神经化学、抗氧化和抗炎作用介导了它们对抑郁症的治疗作用。富含矢车菊素 - 3 - 半乳糖苷和矢车菊素的浆果在开发用于改善心理健康的功能性食品、膳食补充剂和药物制剂方面可能具有重要价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/a6dc6df5143c/FSN3-12-6315-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/4d8f399cb3cf/FSN3-12-6315-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/f6f7ccd00785/FSN3-12-6315-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/8e26dbe1569d/FSN3-12-6315-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/27c02236376f/FSN3-12-6315-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/ebb849f9b2e0/FSN3-12-6315-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/a6dc6df5143c/FSN3-12-6315-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/4d8f399cb3cf/FSN3-12-6315-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/f6f7ccd00785/FSN3-12-6315-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/8e26dbe1569d/FSN3-12-6315-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/27c02236376f/FSN3-12-6315-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/ebb849f9b2e0/FSN3-12-6315-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d1/11561776/a6dc6df5143c/FSN3-12-6315-g007.jpg

相似文献

1
Identification, quantification, and antidepressant-like evaluation of anthocyanin-rich extracts from different dietary berries.不同食用浆果中富含花青素提取物的鉴定、定量及抗抑郁样评估。
Food Sci Nutr. 2024 Jun 14;12(9):6315-6327. doi: 10.1002/fsn3.4280. eCollection 2024 Sep.
2
Contribution of Anthocyanin Composition to Total Antioxidant Capacity of Berries.花色苷组成对浆果总抗氧化能力的贡献
Plant Foods Hum Nutr. 2015 Dec;70(4):427-32. doi: 10.1007/s11130-015-0514-5.
3
Identification of Anthocyanins from Four Kinds of Berries and Their Inhibition Activity to α-Glycosidase and Protein Tyrosine Phosphatase 1B by HPLC-FT-ICR MS/MS.通过高效液相色谱-傅里叶变换离子回旋共振质谱联用技术鉴定四种浆果中的花色苷及其对α-糖苷酶和蛋白酪氨酸磷酸酶 1B 的抑制活性。
J Agric Food Chem. 2017 Aug 2;65(30):6211-6221. doi: 10.1021/acs.jafc.7b02550. Epub 2017 Jul 21.
4
Identification of anthocyanins in deep colored berries and grains in China.中国深色浆果和谷物中花色苷的鉴定
Food Chem X. 2024 Jun 27;23:101602. doi: 10.1016/j.fochx.2024.101602. eCollection 2024 Oct 30.
5
Anthocyanin Profile and Antioxidant Activity of Various Berries Cultivated in Korea.韩国种植的各种浆果的花色苷谱及抗氧化活性
Nat Prod Commun. 2015 Jun;10(6):963-8.
6
Saskatoon and wild blueberries have higher anthocyanin contents than other Manitoba berries.萨斯卡通莓和野生蓝莓的花青素含量高于曼尼托巴省的其他浆果。
J Agric Food Chem. 2007 Dec 26;55(26):10832-8. doi: 10.1021/jf072529m. Epub 2007 Dec 5.
7
Phytochemical properties and antioxidant capacities of various colored berries.各种彩色浆果的植物化学特性和抗氧化能力。
J Sci Food Agric. 2014 Jan 30;94(2):180-8. doi: 10.1002/jsfa.6216. Epub 2013 Jul 4.
8
Variations in Anthocyanin Profiles and Antioxidant Activity of 12 Genotypes of Mulberry ( spp.) Fruits and Their Changes during Processing.12个桑树种质果实的花色苷谱及抗氧化活性变化及其加工过程中的变化
Antioxidants (Basel). 2020 Mar 17;9(3):242. doi: 10.3390/antiox9030242.
9
Berries grown in Brazil: anthocyanin profiles and biological properties.巴西莓：花色苷成分及生物特性。
J Sci Food Agric. 2018 Aug;98(11):4331-4338. doi: 10.1002/jsfa.8959. Epub 2018 Apr 18.
10
Comprehensive structural analysis of polyphenols and their enzymatic inhibition activities and antioxidant capacity of black mulberry (Morus nigra L.).全面分析桑椹（Morus nigra L.）中的多酚及其酶抑制活性和抗氧化能力。
Food Chem. 2023 Nov 30;427:136605. doi: 10.1016/j.foodchem.2023.136605. Epub 2023 Jun 19.

引用本文的文献

1
Urolithin A Exhibits Antidepressant-like Effects by Modulating the AMPK/CREB/BDNF Pathway.尿石素A通过调节AMPK/CREB/BDNF通路发挥抗抑郁样作用。
Nutrients. 2025 Jul 11;17(14):2294. doi: 10.3390/nu17142294.

本文引用的文献

1
Mitochondrial dynamics dysfunction: Unraveling the hidden link to depression.线粒体动态失衡：揭示与抑郁症的潜在关联。
Biomed Pharmacother. 2024 Jun;175:116656. doi: 10.1016/j.biopha.2024.116656. Epub 2024 Apr 27.
2
Inflammation as a mediator between adverse childhood experiences and adult depression: A meta-analytic structural equation model.炎症作为不良童年经历与成人抑郁之间的中介：一项荟萃分析结构方程模型。
J Affect Disord. 2024 Jul 15;357:85-96. doi: 10.1016/j.jad.2024.04.072. Epub 2024 Apr 25.
3
Dietary Sources, Stabilization, Health Benefits, and Industrial Application of Anthocyanins-A Review.
花色苷的膳食来源、稳定性、健康益处及工业应用——综述
Foods. 2024 Apr 17;13(8):1227. doi: 10.3390/foods13081227.
4
Chokeberry reduces inflammation in human preadipocytes.黑果腺肋花楸能减轻人类前脂肪细胞中的炎症。
J Funct Foods. 2024 Jan;112. doi: 10.1016/j.jff.2023.105947. Epub 2023 Dec 15.
5
Anthocyanins from blueberry ameliorated arsenic-induced memory impairment, oxidative stress, and mitochondrial-biosynthesis imbalance in rat hippocampal neurons.蓝莓花色苷改善了砷诱导的大鼠海马神经元记忆损伤、氧化应激和线粒体生物合成失衡。
Cell Signal. 2024 Jul;119:111177. doi: 10.1016/j.cellsig.2024.111177. Epub 2024 Apr 15.
6
Microencapsulation with fructooligosaccharides and whey protein enhances the antioxidant activity of anthocyanins and their ability to modulate gut microbiota in vitro.用低聚果糖和乳清蛋白进行微胶囊化可以提高花色苷的抗氧化活性，并增强其在体外调节肠道微生物群的能力。
Food Res Int. 2024 Apr;181:114082. doi: 10.1016/j.foodres.2024.114082. Epub 2024 Feb 9.
7
Quercetin increases the antidepressant-like effects of sclareol and antagonizes diazepam in thiopental sodium-induced sleeping mice: A possible GABAergic transmission intervention.槲皮素增加了藏红花醇的抗抑郁样作用，并拮抗了戊巴比妥钠诱导睡眠的小鼠中的地西泮：一种可能的 GABA 能传递干预。
Phytother Res. 2024 May;38(5):2198-2214. doi: 10.1002/ptr.8139. Epub 2024 Feb 27.
8
Anthocyanins-natural pigment of colored rice bran: Composition and biological activities.花色苷——有色米糠的天然色素：组成与生物活性。
Food Res Int. 2024 Jan;175:113722. doi: 10.1016/j.foodres.2023.113722. Epub 2023 Nov 23.
9
Anthocyanins: Molecular Aspects on Their Neuroprotective Activity.花色苷：其神经保护活性的分子方面。
Biomolecules. 2023 Oct 31;13(11):1598. doi: 10.3390/biom13111598.
10
Red Cabbage Anthocyanins Attenuate Cognitive Impairment By Attenuating Neuroinflammation and Regulating Gut Microbiota in Aging Mice.红甘蓝花色苷通过减轻衰老小鼠神经炎症和调节肠道微生物群来减轻认知障碍。
J Agric Food Chem. 2023 Oct 18;71(41):15064-15072. doi: 10.1021/acs.jafc.3c03183. Epub 2023 Oct 2.